CLINICAL TRIALS PROFILE FOR SIKLOS

All Clinical Trials for SIKLOS

Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
NCT01976416 ↗	Novel Use Of Hydroxyurea in an African Region With Malaria	Completed	Children's Hospital Medical Center, Cincinnati	Phase 3	2014-09-01	Multiple studies have shown that hydroxyurea has clinical efficacy in preventing acute painful episodes and reducing the need for blood transfusions in children with sickle cell anemia (SCA), but no study has been conducted in malaria endemic regions of sub-Saharan Africa, the areas with the most children with SCA. The primary goal of this study is to investigate the safety and efficacy of hydroxyurea for children with SCA in a malaria endemic region within sub-Saharan Africa.
NCT01976416 ↗	Novel Use Of Hydroxyurea in an African Region With Malaria	Completed	Doris Duke Charitable Foundation	Phase 3	2014-09-01	Multiple studies have shown that hydroxyurea has clinical efficacy in preventing acute painful episodes and reducing the need for blood transfusions in children with sickle cell anemia (SCA), but no study has been conducted in malaria endemic regions of sub-Saharan Africa, the areas with the most children with SCA. The primary goal of this study is to investigate the safety and efficacy of hydroxyurea for children with SCA in a malaria endemic region within sub-Saharan Africa.
NCT01976416 ↗	Novel Use Of Hydroxyurea in an African Region With Malaria	Completed	Makerere University	Phase 3	2014-09-01	Multiple studies have shown that hydroxyurea has clinical efficacy in preventing acute painful episodes and reducing the need for blood transfusions in children with sickle cell anemia (SCA), but no study has been conducted in malaria endemic regions of sub-Saharan Africa, the areas with the most children with SCA. The primary goal of this study is to investigate the safety and efficacy of hydroxyurea for children with SCA in a malaria endemic region within sub-Saharan Africa.
NCT01976416 ↗	Novel Use Of Hydroxyurea in an African Region With Malaria	Completed	Mulago Hospital, Uganda	Phase 3	2014-09-01	Multiple studies have shown that hydroxyurea has clinical efficacy in preventing acute painful episodes and reducing the need for blood transfusions in children with sickle cell anemia (SCA), but no study has been conducted in malaria endemic regions of sub-Saharan Africa, the areas with the most children with SCA. The primary goal of this study is to investigate the safety and efficacy of hydroxyurea for children with SCA in a malaria endemic region within sub-Saharan Africa.
NCT01976416 ↗	Novel Use Of Hydroxyurea in an African Region With Malaria	Completed	Indiana University	Phase 3	2014-09-01	Multiple studies have shown that hydroxyurea has clinical efficacy in preventing acute painful episodes and reducing the need for blood transfusions in children with sickle cell anemia (SCA), but no study has been conducted in malaria endemic regions of sub-Saharan Africa, the areas with the most children with SCA. The primary goal of this study is to investigate the safety and efficacy of hydroxyurea for children with SCA in a malaria endemic region within sub-Saharan Africa.

Clinical Trial Conditions for SIKLOS

Condition Name

Condition Name for SIKLOS
Intervention	Trials
Sickle Cell Disease	7
Malaria	2
Sickle Cell Anemia	2
Healthy Volunteers	1

Condition MeSH

Condition MeSH for SIKLOS
Intervention	Trials
Anemia, Sickle Cell	8
Malaria	2
Anemia	2
Renal Insufficiency	1

Clinical Trial Locations for SIKLOS

Trials by Country

Trials by Country for SIKLOS
Location	Trials
France	7
Uganda	3
Greece	1
Martinique	1
United States	1

Trials by US State

Trials by US State for SIKLOS
Location	Trials
Texas	1

Clinical Trial Progress for SIKLOS

Clinical Trial Phase

Clinical Trial Phase for SIKLOS
Clinical Trial Phase	Trials
Phase 4	1
Phase 3	3
Phase 2	2

Clinical Trial Status

Clinical Trial Status for SIKLOS
Clinical Trial Phase	Trials
Completed	6
Recruiting	3

Clinical Trial Sponsors for SIKLOS

Sponsor Name

Sponsor Name for SIKLOS
Sponsor	Trials
ADDMEDICA SASA	5
Children's Hospital Medical Center, Cincinnati	3
Makerere University	3

Sponsor Type

Sponsor Type for SIKLOS
Sponsor	Trials
Other	21
Industry	6
NIH	1