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Last Updated: December 23, 2024

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CLINICAL TRIALS PROFILE FOR SIRTURO


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All Clinical Trials for SIRTURO

Trial ID Title Status Sponsor Phase Start Date Summary
NCT02193776 ↗ A Phase 2 to Evaluate the Efficacy, Safety and Tolerability of Combinations of Bedaquiline, Moxifloxacin, PA-824 and Pyrazinamide in Adult Subjects With Drug-Sensitive or Multi Drug-Resistant Pulmonary Tuberculosis. Completed Global Alliance for TB Drug Development Phase 2 2014-10-23 The purpose of this study is to determine the mycobactericidal activity of combinations of bedaquiline (J), moxifloxacin (M), PA-824 (Pa) and pyrazinamide (Z) regimens during 8 weeks of treatment.
NCT02409290 ↗ The Evaluation of a Standard Treatment Regimen of Anti-tuberculosis Drugs for Patients With MDR-TB Active, not recruiting Institute of Tropical Medicine, Belgium Phase 3 2016-04-01 Tuberculosis (TB) is a common, infectious, bacterial disease that is spread when an infected person transmits their saliva through the air by coughing or sneezing. Despite the availability and effectiveness of affordable six-month treatments for tuberculosis (TB), the worldwide control of this disease is currently being impacted by the emergence of multidrug resistant TB (MDR-TB). MDR-TB refers to TB that is resistant to at least isoniazid and rifampicin. These are the two most powerful first-line drugs used to treat pulmonary TB. MDR-TB usually develops while a person is taking TB treatment due to either inappropriate treatment or failure of patients to comply with their treatment. This strain of drug-resistant bacteria can also be spread to other people through the air. With the incident rate of MDR-TB on the rise, there is a need to investigate optimal treatment regimens using effective drugs.
NCT02409290 ↗ The Evaluation of a Standard Treatment Regimen of Anti-tuberculosis Drugs for Patients With MDR-TB Active, not recruiting Liverpool School of Tropical Medicine Phase 3 2016-04-01 Tuberculosis (TB) is a common, infectious, bacterial disease that is spread when an infected person transmits their saliva through the air by coughing or sneezing. Despite the availability and effectiveness of affordable six-month treatments for tuberculosis (TB), the worldwide control of this disease is currently being impacted by the emergence of multidrug resistant TB (MDR-TB). MDR-TB refers to TB that is resistant to at least isoniazid and rifampicin. These are the two most powerful first-line drugs used to treat pulmonary TB. MDR-TB usually develops while a person is taking TB treatment due to either inappropriate treatment or failure of patients to comply with their treatment. This strain of drug-resistant bacteria can also be spread to other people through the air. With the incident rate of MDR-TB on the rise, there is a need to investigate optimal treatment regimens using effective drugs.
NCT02409290 ↗ The Evaluation of a Standard Treatment Regimen of Anti-tuberculosis Drugs for Patients With MDR-TB Active, not recruiting Medical Research Council Phase 3 2016-04-01 Tuberculosis (TB) is a common, infectious, bacterial disease that is spread when an infected person transmits their saliva through the air by coughing or sneezing. Despite the availability and effectiveness of affordable six-month treatments for tuberculosis (TB), the worldwide control of this disease is currently being impacted by the emergence of multidrug resistant TB (MDR-TB). MDR-TB refers to TB that is resistant to at least isoniazid and rifampicin. These are the two most powerful first-line drugs used to treat pulmonary TB. MDR-TB usually develops while a person is taking TB treatment due to either inappropriate treatment or failure of patients to comply with their treatment. This strain of drug-resistant bacteria can also be spread to other people through the air. With the incident rate of MDR-TB on the rise, there is a need to investigate optimal treatment regimens using effective drugs.
NCT02409290 ↗ The Evaluation of a Standard Treatment Regimen of Anti-tuberculosis Drugs for Patients With MDR-TB Active, not recruiting Rede TB Phase 3 2016-04-01 Tuberculosis (TB) is a common, infectious, bacterial disease that is spread when an infected person transmits their saliva through the air by coughing or sneezing. Despite the availability and effectiveness of affordable six-month treatments for tuberculosis (TB), the worldwide control of this disease is currently being impacted by the emergence of multidrug resistant TB (MDR-TB). MDR-TB refers to TB that is resistant to at least isoniazid and rifampicin. These are the two most powerful first-line drugs used to treat pulmonary TB. MDR-TB usually develops while a person is taking TB treatment due to either inappropriate treatment or failure of patients to comply with their treatment. This strain of drug-resistant bacteria can also be spread to other people through the air. With the incident rate of MDR-TB on the rise, there is a need to investigate optimal treatment regimens using effective drugs.
NCT02409290 ↗ The Evaluation of a Standard Treatment Regimen of Anti-tuberculosis Drugs for Patients With MDR-TB Active, not recruiting IUATLD, Inc Phase 3 2016-04-01 Tuberculosis (TB) is a common, infectious, bacterial disease that is spread when an infected person transmits their saliva through the air by coughing or sneezing. Despite the availability and effectiveness of affordable six-month treatments for tuberculosis (TB), the worldwide control of this disease is currently being impacted by the emergence of multidrug resistant TB (MDR-TB). MDR-TB refers to TB that is resistant to at least isoniazid and rifampicin. These are the two most powerful first-line drugs used to treat pulmonary TB. MDR-TB usually develops while a person is taking TB treatment due to either inappropriate treatment or failure of patients to comply with their treatment. This strain of drug-resistant bacteria can also be spread to other people through the air. With the incident rate of MDR-TB on the rise, there is a need to investigate optimal treatment regimens using effective drugs.
NCT02583048 ↗ Evaluating the Safety, Tolerability, and Pharmacokinetics of Bedaquiline and Delamanid, Alone and in Combination, For Drug-Resistant Pulmonary Tuberculosis Completed National Institute of Allergy and Infectious Diseases (NIAID) Phase 2 2016-08-15 This study evaluated the safety, tolerability, and pharmacokinetics of the anti-tuberculosis (TB) drugs bedaquiline (BDQ) and delamanid (DLM), alone and in combination, among participants (with or without HIV co-infection) taking multidrug treatment for multidrug-resistant tuberculosis (MDR-TB) or rifampin-monoresistant TB (RR-TB).
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for SIRTURO

Condition Name

Condition Name for SIRTURO
Intervention Trials
Tuberculosis, Multidrug-Resistant 5
Extensively Drug-Resistant Tuberculosis 5
Tuberculosis 5
Tuberculosis, Pulmonary 3
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Condition MeSH

Condition MeSH for SIRTURO
Intervention Trials
Tuberculosis 15
Tuberculosis, Multidrug-Resistant 10
Tuberculosis, Pulmonary 9
Extensively Drug-Resistant Tuberculosis 5
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Clinical Trial Locations for SIRTURO

Trials by Country

Trials by Country for SIRTURO
Location Trials
South Africa 25
Uzbekistan 6
Georgia 4
United States 4
Belarus 4
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Trials by US State

Trials by US State for SIRTURO
Location Trials
Washington 1
Texas 1
New York 1
Colorado 1
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Clinical Trial Progress for SIRTURO

Clinical Trial Phase

Clinical Trial Phase for SIRTURO
Clinical Trial Phase Trials
Phase 4 1
Phase 3 4
Phase 2/Phase 3 5
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Clinical Trial Status

Clinical Trial Status for SIRTURO
Clinical Trial Phase Trials
Recruiting 5
Active, not recruiting 4
Completed 4
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Clinical Trial Sponsors for SIRTURO

Sponsor Name

Sponsor Name for SIRTURO
Sponsor Trials
Wits Health Consortium (Pty) Ltd 5
Global Alliance for TB Drug Development 5
London School of Hygiene and Tropical Medicine 4
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Sponsor Type

Sponsor Type for SIRTURO
Sponsor Trials
Other 100
Industry 6
NIH 4
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