Fluoride Availability in Saliva After Use of Sodium Fluoride or Monofluorophosphate Toothpastes
Completed
University of Campinas, Brazil
Phase 1
2011-08-01
Considering the widespread use of sodium fluoride (NaF) and monofluorophosphate (MFP) based
toothpastes, the present study aim to evaluate F availability in saliva after use of the
top-selling Brazilian toothpastes. In a blind, crossover clinical trial study, volunteers
will brush their teeth with one of the following toothpastes: 1) non-fluoride toothpaste
(negative control group); 2) NaF/silica based toothpaste 3)MFP/calcium carbonate based
toothpaste. After brushing, a rinse with purified water will be performed. Unstimulated
saliva will be collected before and up to 60 min after brushing. Ionic fluoride and total
soluble fluoride (corresponding to the sum of fluoride as ion and as MFP) will be determined
after acid treatment of salivary samples to hydrolyze MFP. Fluoride will be determined using
an ion selective electrode.
Clinical Efficacy of a Toothpaste in Providing Relief From the Pain of Dentinal Hypersensitivity
Completed
GlaxoSmithKline
Phase 3
2012-04-01
A study to compare the efficacy of a test dentifrice against a control dentifrice in reducing
dentinal hypersensitivity over a two week treatment period.
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