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Last Updated: November 8, 2024

CLINICAL TRIALS PROFILE FOR SPRYCEL


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All Clinical Trials for SPRYCEL

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00036738 ↗ Fludarabine Phosphate and Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Acute Lymphoblastic Leukemia or Chronic Myelogenous Leukemia That Has Responded to Treatment With Imatinib Mesylate, D Completed National Cancer Institute (NCI) Phase 2 2001-07-13 This phase II trial is studying how well fludarabine phosphate and total-body irradiation followed by donor peripheral blood stem cell transplant work in treating patients with acute lymphoblastic leukemia or chronic myelogenous leukemia that has responded to previous treatment with imatinib mesylate, dasatinib, or nilotinib. Giving low doses of chemotherapy, such as fludarabine phosphate, and total-body irradiation (TBI) before a donor peripheral blood stem cell transplant helps stop the growth of cancer cells. It may also stop the patient's immune system from rejecting the donor's stem cells. The donated stem cells may replace the patient's immune system and help destroy any remaining cancer cells (graft-versus-tumor effect). Giving an infusion of the donor's T cells (donor lymphocyte infusion) after the transplant may help increase this effect. Sometimes the transplanted cells from a donor can also make an immune response against the body's normal cells. Giving mycophenolate mofetil and cyclosporine after the transplant may stop this from happening.
NCT00036738 ↗ Fludarabine Phosphate and Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Acute Lymphoblastic Leukemia or Chronic Myelogenous Leukemia That Has Responded to Treatment With Imatinib Mesylate, D Completed Fred Hutchinson Cancer Research Center Phase 2 2001-07-13 This phase II trial is studying how well fludarabine phosphate and total-body irradiation followed by donor peripheral blood stem cell transplant work in treating patients with acute lymphoblastic leukemia or chronic myelogenous leukemia that has responded to previous treatment with imatinib mesylate, dasatinib, or nilotinib. Giving low doses of chemotherapy, such as fludarabine phosphate, and total-body irradiation (TBI) before a donor peripheral blood stem cell transplant helps stop the growth of cancer cells. It may also stop the patient's immune system from rejecting the donor's stem cells. The donated stem cells may replace the patient's immune system and help destroy any remaining cancer cells (graft-versus-tumor effect). Giving an infusion of the donor's T cells (donor lymphocyte infusion) after the transplant may help increase this effect. Sometimes the transplanted cells from a donor can also make an immune response against the body's normal cells. Giving mycophenolate mofetil and cyclosporine after the transplant may stop this from happening.
NCT00070499 ↗ Imatinib Mesylate or Dasatinib in Treating Patients With Previously Untreated Chronic Phase Chronic Myelogenous Leukemia Active, not recruiting National Cancer Institute (NCI) Phase 2 2004-08-15 This randomized phase IIB trial studies imatinib mesylate at two different doses and dasatinib to see how well they work in treating patients with previously untreated chronic phase chronic myelogenous leukemia. Imatinib mesylate or dasatinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.
NCT00099606 ↗ Phase I (PH I) Mad Refractory Solid Tumor Study Completed Bristol-Myers Squibb Phase 1 2004-07-01 The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, effect of food, and continue exploratory research of BMS-354825 in patients with solid tumors not responding to standard treatment, or for which no effective standard treatment exists.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for SPRYCEL

Condition Name

Condition Name for SPRYCEL
Intervention Trials
Leukemia 12
Chronic Myeloid Leukemia 10
Breast Cancer 9
Acute Lymphoblastic Leukemia 9
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Condition MeSH

Condition MeSH for SPRYCEL
Intervention Trials
Leukemia 81
Leukemia, Myeloid 56
Leukemia, Myelogenous, Chronic, BCR-ABL Positive 53
Leukemia, Lymphoid 34
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Clinical Trial Locations for SPRYCEL

Trials by Country

Trials by Country for SPRYCEL
Location Trials
United States 996
Canada 74
United Kingdom 59
Australia 43
Japan 33
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Trials by US State

Trials by US State for SPRYCEL
Location Trials
Texas 67
California 47
Illinois 40
New York 39
Pennsylvania 37
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Clinical Trial Progress for SPRYCEL

Clinical Trial Phase

Clinical Trial Phase for SPRYCEL
Clinical Trial Phase Trials
Phase 4 4
Phase 3 11
Phase 2/Phase 3 1
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Clinical Trial Status

Clinical Trial Status for SPRYCEL
Clinical Trial Phase Trials
Completed 83
Terminated 31
Recruiting 21
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Clinical Trial Sponsors for SPRYCEL

Sponsor Name

Sponsor Name for SPRYCEL
Sponsor Trials
Bristol-Myers Squibb 74
National Cancer Institute (NCI) 57
M.D. Anderson Cancer Center 24
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Sponsor Type

Sponsor Type for SPRYCEL
Sponsor Trials
Other 164
Industry 108
NIH 58
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