Bevacizumab, Chemotherapy and Valproic Acid in Advanced Sarcomas
Completed
Genentech, Inc.
Phase 1
2010-09-01
The purpose of this study is to test the combination of the chemotherapy drugs Gemcitabine,
bevacizumab, and docetaxel with valproic acid to treat patients with metastatic sarcoma.
Valproic acid is used by people who have seizures to prevent seizures from happening;
however, its use in cancer is investigational. This study will help define the proper dosing
of this valproic acid. We will assess the safety of valproic acid with the combination of the
above chemotherapy drugs and check for possible side effects. Valproic acid may improve the
function of the chemotherapy drugs against the cancer.
Bevacizumab, Chemotherapy and Valproic Acid in Advanced Sarcomas
Completed
Mohammed M Milhem
Phase 1
2010-09-01
The purpose of this study is to test the combination of the chemotherapy drugs Gemcitabine,
bevacizumab, and docetaxel with valproic acid to treat patients with metastatic sarcoma.
Valproic acid is used by people who have seizures to prevent seizures from happening;
however, its use in cancer is investigational. This study will help define the proper dosing
of this valproic acid. We will assess the safety of valproic acid with the combination of the
above chemotherapy drugs and check for possible side effects. Valproic acid may improve the
function of the chemotherapy drugs against the cancer.
Bevacizumab, Chemotherapy and Valproic Acid in Advanced Sarcomas
Completed
University of Iowa
Phase 1
2010-09-01
The purpose of this study is to test the combination of the chemotherapy drugs Gemcitabine,
bevacizumab, and docetaxel with valproic acid to treat patients with metastatic sarcoma.
Valproic acid is used by people who have seizures to prevent seizures from happening;
however, its use in cancer is investigational. This study will help define the proper dosing
of this valproic acid. We will assess the safety of valproic acid with the combination of the
above chemotherapy drugs and check for possible side effects. Valproic acid may improve the
function of the chemotherapy drugs against the cancer.
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