Effect of Ertugliflozin on Cardiac Function in Diabetes
Recruiting
MSD Korea Ltd.
Phase 3
2019-06-01
The aim of this study is to investigate the beneficial role of ertugliflozin, a new SGLT2
inhibitor, in cardiac function via measuring GLS as well as other hemodynamic factors using
echocardiogram in patients with T2D and HF, who are not controlled with oral antidiabetic
medications including DPP4 inhibitors.
Effect of Ertugliflozin on Cardiac Function in Diabetes
Recruiting
Soo Lim
Phase 3
2019-06-01
The aim of this study is to investigate the beneficial role of ertugliflozin, a new SGLT2
inhibitor, in cardiac function via measuring GLS as well as other hemodynamic factors using
echocardiogram in patients with T2D and HF, who are not controlled with oral antidiabetic
medications including DPP4 inhibitors.
Renal Oxygenation, Oxygen Consumption and Hemodynamic Kinetics in Type 2 DIabetes: an Ertugliflozin Study.
Recruiting
VU University Medical Center
Phase 4
2020-12-10
Current study will render insight in to the role of renal hypoxia in the diabetic kidney and
is able to associate its finding with measurements of renal perfusion and glomerular
filtration rate. Moreover, this research will focus on the effects of sodium-glucose
cotransporter 2 inhibition on renal tissue oxygenation and oxygen consumption as well as a
change in intrarenal hemodynamics and perfusion, and a shift of fuel metabolites. Elucidation
the mechanisms underlying the effects of SGLT2 inhibition will advance our knowledge and
contribute to their optimal clinical utilization in the treatment of chronic kidney disease
in diabetes and possibly beyond.
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