The Effect of Sodium Thiosulfate Eardrops on Hearing Loss in Patients Who Receive Cisplatin Therapy
Terminated
Sidney Kimmel Cancer Center at Thomas Jefferson University
N/A
2011-08-24
This is a pilot, randomized, self-controlled study of the effects of intratympanic sodium
thiosulfate (STS) on the degree of hearing loss in patients receiving cisplatin therapy.
Sodium thiosulfate is an inactive ingredient contained in sulfacetamide ophthalmic solution
which is used routinely as an otic solution delivered to the middle ear space.
The hypothesis of this study is that local administration of sodium thiosulfate (STS) will
result in improved hearing compared to ears not receiving the study drug in patients
receiving systemic cisplatin therapy.
Toxicity and Efficacy Evaluation of Topical Minoxidil in Acne Vulgaris
Recruiting
Chang Gung Memorial Hospital
Phase 1/Phase 2
2023-07-11
Patients with acne vulgaris (AV) appeared to be a chronic inflammation with a wide range in
teenagers and adult. The protocol design is as follows.
The subjects enrolled through inclusion and exclusion criteria will undergo the blood and
urine biochemical tests for baseline record. The photos from the subjects will be recorded
per day, and the blood and urine biochemical tests will be recorded per week.
Objectives: primary: to test the toxicity of topical minoxidil in treatment of acne vulgaris;
second: to evaluate the response and disease control rate in this pilot study.
Measurement: Time to resolution of individual acne lesions (14 days) Monitor of treatment
efficacy: number of inflammatory acne lesions counting, time to resolution of individual acne
lesion, and degree of acne severity measurement.
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