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Last Updated: November 25, 2024

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CLINICAL TRIALS PROFILE FOR TAGRISSO


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All Clinical Trials for TAGRISSO

Trial ID Title Status Sponsor Phase Start Date Summary
NCT02465060 ↗ Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial) Recruiting National Cancer Institute (NCI) Phase 2 2015-08-12 This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Genetic tests look at the unique genetic material (genes) of patients' tumor cells. Patients with genetic abnormalities (such as mutations, amplifications, or translocations) may benefit more from treatment which targets their tumor's particular genetic abnormality. Identifying these genetic abnormalities first may help doctors plan better treatment for patients with solid tumors, lymphomas, or multiple myeloma.
NCT02496663 ↗ Osimertinib and Necitumumab in Treating Patients With EGFR-Mutant Stage IV or Recurrent Non-small Cell Lung Cancer Who Have Progressed on a Previous EGFR Tyrosine Kinase Inhibitor Active, not recruiting National Cancer Institute (NCI) Phase 1 2016-03-24 This phase I trial studies the side effects and best dose of necitumumab when given together with osimertinib in treating patients with EGFR-mutant non-small cell lung cancer that is stage IV or has come back (recurrent) and who have progressed on a previous EGFR tyrosine kinase inhibitor. Immunotherapy with monoclonal antibodies, such as necitumumab, may induce changes in body's immune system and may interfere with the ability of tumor cells to grow and spread. Osimertinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving necitumumab with osimertinib may be a better treatment for EGFR-mutant non-small cell lung cancer.
NCT02503722 ↗ Testing the Combination of MLN0128 (TAK-228) and AZD9291 in Advanced EGFR (Epidermal Growth Factor Receptor) Mutation Positive Non-small Cell Lung Cancer Active, not recruiting National Cancer Institute (NCI) Phase 1 2016-10-13 This phase I trial studies the side effects and best dose of sapanisertib when given together with osimertinib in treating patients with stage IV EGFR mutation positive non-small cell lung cancer that has progressed after treatment with an EGFR tyrosine kinase inhibitor. Sapanisertib and osimertinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for TAGRISSO

Condition Name

Condition Name for TAGRISSO
Intervention Trials
Stage IV Lung Cancer AJCC v8 11
Non-small Cell Lung Cancer 10
Stage IVA Lung Cancer AJCC v8 10
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Condition MeSH

Condition MeSH for TAGRISSO
Intervention Trials
Carcinoma, Non-Small-Cell Lung 54
Lung Neoplasms 42
Carcinoma 19
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Clinical Trial Locations for TAGRISSO

Trials by Country

Trials by Country for TAGRISSO
Location Trials
United States 266
China 23
Italy 21
Korea, Republic of 20
France 15
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Trials by US State

Trials by US State for TAGRISSO
Location Trials
California 23
Texas 14
Massachusetts 13
Ohio 12
Florida 11
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Clinical Trial Progress for TAGRISSO

Clinical Trial Phase

Clinical Trial Phase for TAGRISSO
Clinical Trial Phase Trials
Phase 3 6
Phase 2 32
Phase 1/Phase 2 11
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Clinical Trial Status

Clinical Trial Status for TAGRISSO
Clinical Trial Phase Trials
Recruiting 30
Not yet recruiting 20
Active, not recruiting 15
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Clinical Trial Sponsors for TAGRISSO

Sponsor Name

Sponsor Name for TAGRISSO
Sponsor Trials
National Cancer Institute (NCI) 19
AstraZeneca 17
M.D. Anderson Cancer Center 4
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Sponsor Type

Sponsor Type for TAGRISSO
Sponsor Trials
Other 52
Industry 41
NIH 19
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