Adjuvant Hormone Therapy in Treating Women With Operable Breast Cancer
Unknown status
Cancer Research UK
Phase 3
1987-09-01
RATIONALE: Estrogen can stimulate the growth of breast cancer cells. Hormone therapy using
tamoxifen may fight breast cancer by blocking the uptake of estrogen.
PURPOSE: Phase III trial to compare the effectiveness of adjuvant therapy using tamoxifen or
ovarian ablation with goserelin or both in treating women with stage I or stage II breast
cancer.
Surgery With or Without Lymph Node Removal in Treating Older Women With Stage I or Stage IIA Breast Cancer
Completed
International Breast Cancer Study Group
Phase 3
1993-05-01
RATIONALE: Removing axillary lymph nodes may be effective in stopping the spread of breast
cancer cells. It is not yet known if surgery to remove breast cancer is more effective with
or without lymph node removal.
PURPOSE: Randomized phase III trial to compare the effectiveness of breast surgery with or
without removal of axillary lymph nodes in treating women who have stage I or stage IIA
breast cancer.
Hormone Therapy and Chemotherapy in Treating Perimenopausal or Postmenopausal Women With Node-Positive Breast Cancer
Completed
International Breast Cancer Study Group
Phase 3
1993-05-01
RATIONALE: Estrogen can stimulate the growth of breast cancer cells. Hormone therapy may
fight breast cancer by blocking the uptake of estrogen. Drugs used in chemotherapy use
different ways to stop tumor cells from dividing so they stop growing or die. Combining
chemotherapy with hormone therapy may kill more tumor cells. It is not yet known which
treatment regimen is more effective for breast cancer.
PURPOSE: Randomized phase III trial to compare the effectiveness of hormone therapy during or
after combination chemotherapy or hormone therapy alone in treating perimenopausal or
postmenopausal women who have stage II or stage IIIA breast cancer.
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