You're using a free limited version of DrugPatentWatch: Upgrade for Complete Access

Last Updated: November 25, 2024

CLINICAL TRIALS PROFILE FOR TEPOTINIB HYDROCHLORIDE


✉ Email this page to a colleague

« Back to Dashboard


All Clinical Trials for TEPOTINIB HYDROCHLORIDE

Trial ID Title Status Sponsor Phase Start Date Summary
NCT01014936 ↗ First-in-Man, Dose-escalation Trial of C-met Kinase Inhibitor MSC2156119J in Subjects With Advanced Solid Tumors Completed Merck KGaA Phase 1 2009-11-30 This is a an open-label, dose-escalation, first-in-man (FIM) study designed to explore MSC2156119J, in subjects with advanced solid tumors who have not responded to previous therapies or for whom no other therapies are available. Subjects will be assigned one of the dosing regimens: - Regimen 1: MSC2156119J once daily for 14 days, followed by 7 days with no treatment (21-day cycle) - Regimen 2: MSC2156119J three times per week (e.g., Days 1, 3, and 5) for three weeks (21-day cycle) - Regimen 3: MSC2156119J every day for three weeks (21-day cycle)
NCT01014936 ↗ First-in-Man, Dose-escalation Trial of C-met Kinase Inhibitor MSC2156119J in Subjects With Advanced Solid Tumors Completed Merck KGaA, Darmstadt, Germany Phase 1 2009-11-30 This is a an open-label, dose-escalation, first-in-man (FIM) study designed to explore MSC2156119J, in subjects with advanced solid tumors who have not responded to previous therapies or for whom no other therapies are available. Subjects will be assigned one of the dosing regimens: - Regimen 1: MSC2156119J once daily for 14 days, followed by 7 days with no treatment (21-day cycle) - Regimen 2: MSC2156119J three times per week (e.g., Days 1, 3, and 5) for three weeks (21-day cycle) - Regimen 3: MSC2156119J every day for three weeks (21-day cycle)
NCT01014936 ↗ First-in-Man, Dose-escalation Trial of C-met Kinase Inhibitor MSC2156119J in Subjects With Advanced Solid Tumors Completed EMD Serono Phase 1 2009-11-30 This is a an open-label, dose-escalation, first-in-man (FIM) study designed to explore MSC2156119J, in subjects with advanced solid tumors who have not responded to previous therapies or for whom no other therapies are available. Subjects will be assigned one of the dosing regimens: - Regimen 1: MSC2156119J once daily for 14 days, followed by 7 days with no treatment (21-day cycle) - Regimen 2: MSC2156119J three times per week (e.g., Days 1, 3, and 5) for three weeks (21-day cycle) - Regimen 3: MSC2156119J every day for three weeks (21-day cycle)
NCT01982955 ↗ Tepotinib With Gefitinib in Participants With Locally Advanced or Metastatic NSCLC (INSIGHT) Completed Merck KGaA Phase 1/Phase 2 2013-12-23 This is a multi-center, open-label, randomized, Phase 1b/2 study to determine the recommended phase 2 dose (RP2D) and to evaluate the efficacy in terms of progression free survival (PFS) of Tepotinib when used in combination with gefitinib in partcipants with T790M negative, MET positive locally advanced or metastatic non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutation and having acquired resistance to Prior EGFR-Tyrosine Kinase Inhibitor (EGFR-TKI) Therapy. This study has 2:1 randomization (Tepotinib/Gefitinib arm versus Chemotherapy arm).
NCT01982955 ↗ Tepotinib With Gefitinib in Participants With Locally Advanced or Metastatic NSCLC (INSIGHT) Completed Merck KGaA, Darmstadt, Germany Phase 1/Phase 2 2013-12-23 This is a multi-center, open-label, randomized, Phase 1b/2 study to determine the recommended phase 2 dose (RP2D) and to evaluate the efficacy in terms of progression free survival (PFS) of Tepotinib when used in combination with gefitinib in partcipants with T790M negative, MET positive locally advanced or metastatic non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutation and having acquired resistance to Prior EGFR-Tyrosine Kinase Inhibitor (EGFR-TKI) Therapy. This study has 2:1 randomization (Tepotinib/Gefitinib arm versus Chemotherapy arm).
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for TEPOTINIB HYDROCHLORIDE

Condition Name

Condition Name for TEPOTINIB HYDROCHLORIDE
Intervention Trials
Healthy 8
Non-small Cell Lung Cancer 3
Carcinoma, Hepatocellular 2
Advanced Gastric and Gastroesophageal Junction Carcinomas With MET Amplification or MET Exon 14 Alterations 1
[disabled in preview] 0
This preview shows a limited data set
Subscribe for full access, or try a Trial

Condition MeSH

Condition MeSH for TEPOTINIB HYDROCHLORIDE
Intervention Trials
Carcinoma, Non-Small-Cell Lung 7
Lung Neoplasms 4
Carcinoma 3
Carcinoma, Hepatocellular 2
[disabled in preview] 0
This preview shows a limited data set
Subscribe for full access, or try a Trial

Clinical Trial Locations for TEPOTINIB HYDROCHLORIDE

Trials by Country

Trials by Country for TEPOTINIB HYDROCHLORIDE
Location Trials
United States 61
Germany 14
China 13
France 11
Korea, Republic of 9
This preview shows a limited data set
Subscribe for full access, or try a Trial

Trials by US State

Trials by US State for TEPOTINIB HYDROCHLORIDE
Location Trials
Texas 6
Florida 4
Washington 3
New York 3
Georgia 3
This preview shows a limited data set
Subscribe for full access, or try a Trial

Clinical Trial Progress for TEPOTINIB HYDROCHLORIDE

Clinical Trial Phase

Clinical Trial Phase for TEPOTINIB HYDROCHLORIDE
Clinical Trial Phase Trials
Phase 2 5
Phase 1/Phase 2 6
Phase 1 12
[disabled in preview] 0
This preview shows a limited data set
Subscribe for full access, or try a Trial

Clinical Trial Status

Clinical Trial Status for TEPOTINIB HYDROCHLORIDE
Clinical Trial Phase Trials
Completed 11
Not yet recruiting 6
Recruiting 5
[disabled in preview] 1
This preview shows a limited data set
Subscribe for full access, or try a Trial

Clinical Trial Sponsors for TEPOTINIB HYDROCHLORIDE

Sponsor Name

Sponsor Name for TEPOTINIB HYDROCHLORIDE
Sponsor Trials
Merck KGaA, Darmstadt, Germany 14
Merck KGaA 10
EMD Serono Research & Development Institute, Inc. 5
[disabled in preview] 5
This preview shows a limited data set
Subscribe for full access, or try a Trial

Sponsor Type

Sponsor Type for TEPOTINIB HYDROCHLORIDE
Sponsor Trials
Industry 36
Other 6
[disabled in preview] 0
This preview shows a limited data set
Subscribe for full access, or try a Trial

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.