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Last Updated: November 5, 2024

CLINICAL TRIALS PROFILE FOR TESTOSTERONE CYPIONATE-ESTRADIOL CYPIONATE


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All Clinical Trials for TESTOSTERONE CYPIONATE-ESTRADIOL CYPIONATE

Trial ID Title Status Sponsor Phase Start Date Summary
NCT01378299 ↗ CYP19A1 (Cytochrome P450 Family 19 Subfamily A Member 1) Gene and Pharmacogenetics of Response to Testosterone Therapy Completed Baylor College of Medicine Phase 1 2011-10-01 Testosterone (T) replacement prevents bone loss and relieves symptoms associated with androgen deficiency in male patients with hypogonadism, but at the expense of an increase in prostate-related adverse events and in the hematocrit values above the normal which may lead to bad circulatory outcomes. Most of the effects of T on the male skeleton are mediated by its conversion to estradiol (E2) by the enzyme aromatase. Genetic variations in the aromatase (CYP19A1) gene result in enzymes with variable activity and variable levels of E2 and T. This project is designed to determine if genetic variations in the CYP19A1 gene will result in differences in the skeletal response and incidence of side effects from T treatment in patients with low T. A large number of male Veterans are on T. Results from this project will help identify patients who would benefit from the therapy from those at risk for side effects, and would definitely have an impact in the future care of these patients and male patients in general once genetic profiling becomes part of the standard of care.
NCT01378299 ↗ CYP19A1 (Cytochrome P450 Family 19 Subfamily A Member 1) Gene and Pharmacogenetics of Response to Testosterone Therapy Completed VA Office of Research and Development Phase 1 2011-10-01 Testosterone (T) replacement prevents bone loss and relieves symptoms associated with androgen deficiency in male patients with hypogonadism, but at the expense of an increase in prostate-related adverse events and in the hematocrit values above the normal which may lead to bad circulatory outcomes. Most of the effects of T on the male skeleton are mediated by its conversion to estradiol (E2) by the enzyme aromatase. Genetic variations in the aromatase (CYP19A1) gene result in enzymes with variable activity and variable levels of E2 and T. This project is designed to determine if genetic variations in the CYP19A1 gene will result in differences in the skeletal response and incidence of side effects from T treatment in patients with low T. A large number of male Veterans are on T. Results from this project will help identify patients who would benefit from the therapy from those at risk for side effects, and would definitely have an impact in the future care of these patients and male patients in general once genetic profiling becomes part of the standard of care.
NCT01750398 ↗ Bipolar Androgen-based Therapy for Prostate Cancer (BAT) Completed Sidney Kimmel Comprehensive Cancer Center Phase 2 2013-01-01 The purpose of this study is to determine the safety and clinical effects of alternating androgen deprivation therapy with testosterone therapy in men with recurrent prostate cancer as first line hormonal therapy, to assess the effect of alternating therapy on quality of life and metabolic changes associated with androgen-deprivation therapy.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for TESTOSTERONE CYPIONATE-ESTRADIOL CYPIONATE

Condition Name

Condition Name for TESTOSTERONE CYPIONATE-ESTRADIOL CYPIONATE
Intervention Trials
Hypogonadism 1
Recurrent Prostate Cancer 1
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Condition MeSH

Condition MeSH for TESTOSTERONE CYPIONATE-ESTRADIOL CYPIONATE
Intervention Trials
Prostatic Neoplasms 1
Hypogonadism 1
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Clinical Trial Locations for TESTOSTERONE CYPIONATE-ESTRADIOL CYPIONATE

Trials by Country

Trials by Country for TESTOSTERONE CYPIONATE-ESTRADIOL CYPIONATE
Location Trials
United States 3
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Trials by US State

Trials by US State for TESTOSTERONE CYPIONATE-ESTRADIOL CYPIONATE
Location Trials
Maryland 1
Texas 1
New Mexico 1
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Clinical Trial Progress for TESTOSTERONE CYPIONATE-ESTRADIOL CYPIONATE

Clinical Trial Phase

Clinical Trial Phase for TESTOSTERONE CYPIONATE-ESTRADIOL CYPIONATE
Clinical Trial Phase Trials
Phase 2 1
Phase 1 1
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Clinical Trial Status

Clinical Trial Status for TESTOSTERONE CYPIONATE-ESTRADIOL CYPIONATE
Clinical Trial Phase Trials
Completed 2
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Clinical Trial Sponsors for TESTOSTERONE CYPIONATE-ESTRADIOL CYPIONATE

Sponsor Name

Sponsor Name for TESTOSTERONE CYPIONATE-ESTRADIOL CYPIONATE
Sponsor Trials
Baylor College of Medicine 1
VA Office of Research and Development 1
Sidney Kimmel Comprehensive Cancer Center 1
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Sponsor Type

Sponsor Type for TESTOSTERONE CYPIONATE-ESTRADIOL CYPIONATE
Sponsor Trials
Other 3
U.S. Fed 1
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