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Last Updated: November 23, 2024

CLINICAL TRIALS PROFILE FOR TETRABENAZINE


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All Clinical Trials for TETRABENAZINE

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00219804 ↗ Efficacy and Safety of Tetrabenazine in Chorea Completed Prestwick Pharmaceuticals Phase 3 1969-12-31 The primary objective of this study was to establish the absolute reduction of chorea in participants with Huntington's disease(HD) treated with tetrabenazine or placebo
NCT00362804 ↗ Tetrabenazine for Partial Responders Completed Stanley Medical Research Institute N/A 2002-02-01 Purpose of Study: A) To improve outcome in large population of antipsychotic patients with schizophrenia or schizoaffective who are only partial responders B) To increase understanding of pharmacology and mechanisms of action underlying antipsychotic effect Hypothesis/Objectives of the Study: Tetrabenazine, through its pre-synaptic action, should augment the post-synaptic effects of an antipsychotic. Background and Rationale for the study: Preliminary evidence that other amine-depleting agents e.g., reserpine, can induce such an effect
NCT00362804 ↗ Tetrabenazine for Partial Responders Completed Centre for Addiction and Mental Health N/A 2002-02-01 Purpose of Study: A) To improve outcome in large population of antipsychotic patients with schizophrenia or schizoaffective who are only partial responders B) To increase understanding of pharmacology and mechanisms of action underlying antipsychotic effect Hypothesis/Objectives of the Study: Tetrabenazine, through its pre-synaptic action, should augment the post-synaptic effects of an antipsychotic. Background and Rationale for the study: Preliminary evidence that other amine-depleting agents e.g., reserpine, can induce such an effect
NCT00632645 ↗ Neuroleptic and Huntington Disease Comparison of : Olanzapine, la Tetrabenazine and Tiapride Completed Assistance Publique - Hôpitaux de Paris Phase 3 2009-04-01 Huntington's disease (HD) is autosomal dominant neurodegenerative disease, starting in average (with high variability) in the fourth decade. The disease progression is classically characterized by a cognitive deterioration (cortical-frontal dementia), motor disorders (associating chorea, dystonia and bradykinesia), psychiatric disturbances (combining depression and irritability) and metabolic disorder (cachexia). The disease is fatal within 15 to 20 years in most patients. HD has no cure. Neuroleptics are the main drug used and the only to demonstrate its efficacy on chorea in clinical trials. But neuroleptics have also beneficial and adverse effects on other disease characteristics (motor, psychiatric, cognitive or metabolic). Their profile between beneficial and adverse effects could be different according the neuroleptics and their classification. The aim of this study is to compare beneficial and adverse effects of 3 different neuroleptics in HD.
NCT00642057 ↗ Compassionate Use of Tetrabenazine in the Treatment of Abnormal Movements Available Christine Hunter 1969-12-31 Although the results of studies looking at tetrabenazine have shown its effectiveness in the management of hyperkinetic(too much) movement disorders, it has not been made available in the U.S. The drug must be obtained from Cambridge Laboratories, the distributor, using an individual IND (#16,161). The cost of the drug is passed on to the patient. The purpose of the protocol is to provide an efficacious drug, with few side effects, in an attempt to get rid of a variety of incapacitating dyskinesias (abnormal movements).
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for TETRABENAZINE

Condition Name

Condition Name for TETRABENAZINE
Intervention Trials
Schizophrenia 2
Healthy 2
Huntington Disease 2
Huntington's Disease 2
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Condition MeSH

Condition MeSH for TETRABENAZINE
Intervention Trials
Huntington Disease 5
Schizophrenia 2
Psychotic Disorders 2
Movement Disorders 2
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Clinical Trial Locations for TETRABENAZINE

Trials by Country

Trials by Country for TETRABENAZINE
Location Trials
United States 29
France 3
Canada 3
India 2
Australia 1
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Trials by US State

Trials by US State for TETRABENAZINE
Location Trials
New York 2
Texas 2
North Carolina 1
New Jersey 1
Nevada 1
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Clinical Trial Progress for TETRABENAZINE

Clinical Trial Phase

Clinical Trial Phase for TETRABENAZINE
Clinical Trial Phase Trials
Phase 4 2
Phase 3 4
Phase 2 1
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Clinical Trial Status

Clinical Trial Status for TETRABENAZINE
Clinical Trial Phase Trials
Completed 10
Recruiting 1
Withdrawn 1
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Clinical Trial Sponsors for TETRABENAZINE

Sponsor Name

Sponsor Name for TETRABENAZINE
Sponsor Trials
Dr. Reddy's Laboratories Limited 2
Joseph Jankovic 1
Canadian Network for Observational Drug Effect Studies, CNODES 1
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Sponsor Type

Sponsor Type for TETRABENAZINE
Sponsor Trials
Other 14
Industry 7
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