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Last Updated: November 22, 2024

CLINICAL TRIALS PROFILE FOR TRANDOLAPRIL; VERAPAMIL HYDROCHLORIDE


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All Clinical Trials for TRANDOLAPRIL; VERAPAMIL HYDROCHLORIDE

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00133692 ↗ INVEST: INternational VErapamil SR Trandolapril STudy Completed Abbott Phase 4 1997-09-01 Because blood pressure affects the heart, blood vessels, kidneys, and the entire body, it is important to keep it as normal as possible. There are several different ways to control blood pressure and to prevent or limit the development of heart disease due to high blood pressure. The purpose of this study is to compare two treatments to see how well they work and the difference in their side effects. One treatment includes the use of a calcium antagonist drug (Isoptin sustained release [SR] or Verapamil SR). The other treatment excludes the calcium antagonist and may include a non-calcium antagonist drug called a beta blocker (Tenormin or Atenolol). Both treatments may also include medication called angiotensin converting enzyme (ACE) inhibitors and water pills. None of the drugs in this study are experimental, they are all approved by the Food and Drug Administration (FDA).
NCT00133692 ↗ INVEST: INternational VErapamil SR Trandolapril STudy Completed University of Florida Phase 4 1997-09-01 Because blood pressure affects the heart, blood vessels, kidneys, and the entire body, it is important to keep it as normal as possible. There are several different ways to control blood pressure and to prevent or limit the development of heart disease due to high blood pressure. The purpose of this study is to compare two treatments to see how well they work and the difference in their side effects. One treatment includes the use of a calcium antagonist drug (Isoptin sustained release [SR] or Verapamil SR). The other treatment excludes the calcium antagonist and may include a non-calcium antagonist drug called a beta blocker (Tenormin or Atenolol). Both treatments may also include medication called angiotensin converting enzyme (ACE) inhibitors and water pills. None of the drugs in this study are experimental, they are all approved by the Food and Drug Administration (FDA).
NCT00234871 ↗ Tarka® vs. Lotrel® in Hypertensive, Diabetic Subjects With Renal Disease (TANDEM) Completed Abbott Phase 4 2004-01-01 The primary objective of this study is to determine if trandolapril/verapamil (Tarka®) is superior to amlodipine/benazepril (Lotrel®) in reduction of albuminuria in hypertensive subjects with Type 2 diabetes mellitus (DM) and diabetic nephropathy
NCT00497666 ↗ Association Between Rosiglitazone Use and Clinical Course of Diabetic Nephropathy: Population-Based Study Unknown status Assaf-Harofeh Medical Center 2007-08-01 Recent data show that Rosiglitazone treatment can reduce proteinuria in diabetic patients. However, currently there are no trials that examine the effects of Rosiglitazone on kidney disease progression, that is, doubling of serum creatinine or time to onset of end-stage renal disease, in patients with diabetic nephropathy. We decided to study retrospectively the possible association between rosiglitazone use and clinical course of diabetic nephropathy, including rate of deterioration of renal function, appearance and progression of microalbuminuria/proteinuria, survival and acceptance to renal replacement therapy.
NCT00503152 ↗ Preventing Microalbuminuria in Type 2 Diabetes Completed Agenzia Italiana del Farmaco Phase 3 2007-05-01 In people with type 2 diabetes, microalbuminuria is a strong, independent risk factor for diabetic nephropathy and cardiovascular morbidity and mortality. ACE inhibitor therapy decreased the risk of microalbuminuria in hypertensive subjects with type 2 diabetes and normoalbuminuria by about 40%. Available data suggest that angiotensin II receptor blockers (ARBs) might have a similar renoprotective effect and that this effect might be increased by combined ACE inhibitor therapy. The study will evaluate the effects, at similar blood pressure control (systolic/diastolic <130/80 mmHg), for a period of three years, of dual renin-angiotensin-system (RAS) blockade by benazepril and valsartan combination therapy as compared to single RAS blockade by benazepril or valsartan alone on microalbuminuria and cardiovascular events in high-risk patients with type 2 diabetes, creatinine <1.5 mg/dl, no evidence of microalbuminuria but at high risk of renal disease, with hypertension and a urinary albumin excretion between 7 and 19 microgram/min. The relationship between albuminuria and cardiovascular outcomes will also be evaluated. The study is expected to show a more effective prevention of microalbuminuria and cardiovascular events with combined than with single drug ACE inhibitor or ARB therapy. As compared to ACE inhibitor, ARB therapy is expected to have a similar effect on microalbuminuria, but an inferior cardioprotective effect. Applied to clinical practice, the findings should help preventing renal and cardiovascular complications, and related treatment costs, of type 2 diabetes.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for TRANDOLAPRIL; VERAPAMIL HYDROCHLORIDE

Condition Name

Condition Name for TRANDOLAPRIL; VERAPAMIL HYDROCHLORIDE
Intervention Trials
Diabetes 4
Hypertension 2
Hypertensive Disease 1
Proteinuria 1
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Condition MeSH

Condition MeSH for TRANDOLAPRIL; VERAPAMIL HYDROCHLORIDE
Intervention Trials
Hypertension 3
Diabetes Mellitus 2
Myocardial Ischemia 1
Coronary Disease 1
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Clinical Trial Locations for TRANDOLAPRIL; VERAPAMIL HYDROCHLORIDE

Trials by Country

Trials by Country for TRANDOLAPRIL; VERAPAMIL HYDROCHLORIDE
Location Trials
Italy 3
United States 1
China 1
Israel 1
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Trials by US State

Trials by US State for TRANDOLAPRIL; VERAPAMIL HYDROCHLORIDE
Location Trials
Florida 1
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Clinical Trial Progress for TRANDOLAPRIL; VERAPAMIL HYDROCHLORIDE

Clinical Trial Phase

Clinical Trial Phase for TRANDOLAPRIL; VERAPAMIL HYDROCHLORIDE
Clinical Trial Phase Trials
Phase 4 3
Phase 3 1
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Clinical Trial Status

Clinical Trial Status for TRANDOLAPRIL; VERAPAMIL HYDROCHLORIDE
Clinical Trial Phase Trials
Completed 3
Unknown status 2
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Clinical Trial Sponsors for TRANDOLAPRIL; VERAPAMIL HYDROCHLORIDE

Sponsor Name

Sponsor Name for TRANDOLAPRIL; VERAPAMIL HYDROCHLORIDE
Sponsor Trials
Abbott 2
University of Florida 1
Assaf-Harofeh Medical Center 1
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Sponsor Type

Sponsor Type for TRANDOLAPRIL; VERAPAMIL HYDROCHLORIDE
Sponsor Trials
Other 5
Industry 2
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