Pentoxifylline (Trental) as a Modulator of Tumor Necrosis Factor and of HIV Replication in Patients With AIDS
Completed
Hoechst Marion Roussel
Phase 1
1969-12-31
To determine whether pentoxifylline lowers tumor necrosis factor (TNF) levels in AIDS
patients. Pentoxifylline decreases tumor necrosis factor (TNF), and therefore should decrease
such TNF-intensified events as cachexia, enhanced HIV expression, and inhibition of
zidovudine (AZT) activity.
Pentoxifylline (Trental) as a Modulator of Tumor Necrosis Factor and of HIV Replication in Patients With AIDS
Completed
National Institute of Allergy and Infectious Diseases (NIAID)
Phase 1
1969-12-31
To determine whether pentoxifylline lowers tumor necrosis factor (TNF) levels in AIDS
patients. Pentoxifylline decreases tumor necrosis factor (TNF), and therefore should decrease
such TNF-intensified events as cachexia, enhanced HIV expression, and inhibition of
zidovudine (AZT) activity.
Study of Daily Pentoxifylline as a Rescue Treatment in Duchenne Muscular Dystrophy
Completed
Cooperative International Neuromuscular Research Group
Phase 1/Phase 2
2005-09-01
The purpose of this study is to see if male children with Duchenne muscular dystrophy (DMD)
have changes in strength when given the drug Pentoxifylline as a rescue treatment. A total of
64 subjects are expected to participate through all other centers of the Cooperative
International Neuromuscular Research Group (CINRG) worldwide.
The primary purpose of this study is to see whether the addition of pentoxifylline to a
steroid regimen is effective in treating deteriorating muscle strength by comparing the
muscle strength of PTX treated subjects and placebo treated subjects.
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