Cardiovascular Effects of Angiotensin (1-7) in Essential Hypertension
Recruiting
Vanderbilt University
Phase 1
2015-01-01
The purpose of this study is to better understand the cardiovascular effects of the
vasodilatory peptide Angiotensin (1-7) in human hypertension. In this study, the
investigators will test the hypothesis that systemic Angiotensin (1-7) infusion produces
negligible effects with intact baroreceptors, and that the cardiovascular effects of this
peptide are unmasked following elimination of baroreflex buffering.
Role of Sympathetic Activity and Splanchnic Capacitance in Hypertension
Recruiting
Vanderbilt University
Phase 1
2015-04-01
The purpose of this study is to better understand the role of the abdominal veins (splanchnic
capacitance) and the sympathetic nervous system in human hypertension. The investigators will
test the hypothesis that constriction of abdominal veins due to sympathetic activation
contributes to human hypertension. Splanchnic capacitance will be assessed in normotensive
and hypertensive subjects at baseline and during acute blockade of the autonomic nervous
system.
Reduction in Splanchnic Capacitance Contributes to Sympathetically Dependent Hypertension in Autonomic
Active, not recruiting
Vanderbilt University
Phase 1
2016-04-01
The purpose of this study is to learn more about the regulation of the veins of the abdomen
by the autonomic (involuntary) nervous system, and how this may affect high blood pressure.
Normally, the autonomic nervous system controls how much blood flows in the veins. In people
with high blood pressure, however, the autonomic nervous system is changed. This change may
affect the way blood flows in the veins of the abdomen which may play a role in their high
blood pressure. About 32 participants will be screened for the study. The investigators
estimate 16 will be eligible to participate in all of the study days.
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