A Phase 1-2 Trial of Cetuximab in Combination With Oxaliplatin, Capecitabine, and Radiation Therapy Followed by Surgery for Locally-advanced Rectal Cancer
Terminated
Bristol-Myers Squibb
Phase 1/Phase 2
2004-06-01
The objectives of this study are to:
1. To assess dose-limiting toxicities (DLTs) of capecitabine +/- oxaliplatin in a
combination regimen with capecitabine and radiotherapy (Phase 1)
2. To determine the maximum-tolerated dose (MTD) when capecitabine
- oxaliplatin in a combination regimen with capecitabine and radiotherapy (Phase 1)
3. To determine the pathologic response rate of cetuximab +/- oxaliplatin in combination
with capecitabine and radiotherapy (Phase 2)
A Phase 1-2 Trial of Cetuximab in Combination With Oxaliplatin, Capecitabine, and Radiation Therapy Followed by Surgery for Locally-advanced Rectal Cancer
Terminated
George Albert Fisher
Phase 1/Phase 2
2004-06-01
The objectives of this study are to:
1. To assess dose-limiting toxicities (DLTs) of capecitabine +/- oxaliplatin in a
combination regimen with capecitabine and radiotherapy (Phase 1)
2. To determine the maximum-tolerated dose (MTD) when capecitabine
- oxaliplatin in a combination regimen with capecitabine and radiotherapy (Phase 1)
3. To determine the pathologic response rate of cetuximab +/- oxaliplatin in combination
with capecitabine and radiotherapy (Phase 2)
This protocol hopes to determine whether the use of dexmedetomidine-ketamine can reduce the
use of standard of care fentanyl-midazolam sedation during bronchoscopy. This may result in
less respiratory depression while providing better compliance with the procedure.
This protocol hopes to determine whether the use of dexmedetomidine-ketamine can reduce the
use of standard of care fentanyl-midazolam sedation during bronchoscopy. This may result in
less respiratory depression while providing better compliance with the procedure.
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