CLINICAL TRIALS PROFILE FOR UNITHROID

All Clinical Trials for UNITHROID

Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
NCT00230802 ↗	Thyroid Hormone Dose Adjustment in Pregnancy	Completed	Harvard Medical School	N/A	2005-07-01	Our aim is to compare the safety and efficacy of 2 different empiric levothyroxine dose adjustment recommendations to be made at the first confirmation of pregnancy in women with a history of hypothyroidism. Subjects will be women with a prior diagnosis of hypothyroidism who are taking thyroid hormone replacement and who are less than 8 weeks pregnant. Upon confirmation of pregnancy, subjects will be randomized to increase their weekly thyroid hormone dose by either 2 or 3 tablets (28 or 42%). Thyroid function will be evaluated every two weeks in the first 20 weeks and then again at week 30 and post-partum. Primary endpoints will be the proportion of women in each group who remain euthyroid throughout the first trimester and throughout pregnancy.
NCT00230802 ↗	Thyroid Hormone Dose Adjustment in Pregnancy	Completed	Harvard Medical School (HMS and HSDM)	N/A	2005-07-01	Our aim is to compare the safety and efficacy of 2 different empiric levothyroxine dose adjustment recommendations to be made at the first confirmation of pregnancy in women with a history of hypothyroidism. Subjects will be women with a prior diagnosis of hypothyroidism who are taking thyroid hormone replacement and who are less than 8 weeks pregnant. Upon confirmation of pregnancy, subjects will be randomized to increase their weekly thyroid hormone dose by either 2 or 3 tablets (28 or 42%). Thyroid function will be evaluated every two weeks in the first 20 weeks and then again at week 30 and post-partum. Primary endpoints will be the proportion of women in each group who remain euthyroid throughout the first trimester and throughout pregnancy.
NCT00230802 ↗	Thyroid Hormone Dose Adjustment in Pregnancy	Completed	Harvard University	N/A	2005-07-01	Our aim is to compare the safety and efficacy of 2 different empiric levothyroxine dose adjustment recommendations to be made at the first confirmation of pregnancy in women with a history of hypothyroidism. Subjects will be women with a prior diagnosis of hypothyroidism who are taking thyroid hormone replacement and who are less than 8 weeks pregnant. Upon confirmation of pregnancy, subjects will be randomized to increase their weekly thyroid hormone dose by either 2 or 3 tablets (28 or 42%). Thyroid function will be evaluated every two weeks in the first 20 weeks and then again at week 30 and post-partum. Primary endpoints will be the proportion of women in each group who remain euthyroid throughout the first trimester and throughout pregnancy.
NCT00230802 ↗	Thyroid Hormone Dose Adjustment in Pregnancy	Completed	Brigham and Women's Hospital	N/A	2005-07-01	Our aim is to compare the safety and efficacy of 2 different empiric levothyroxine dose adjustment recommendations to be made at the first confirmation of pregnancy in women with a history of hypothyroidism. Subjects will be women with a prior diagnosis of hypothyroidism who are taking thyroid hormone replacement and who are less than 8 weeks pregnant. Upon confirmation of pregnancy, subjects will be randomized to increase their weekly thyroid hormone dose by either 2 or 3 tablets (28 or 42%). Thyroid function will be evaluated every two weeks in the first 20 weeks and then again at week 30 and post-partum. Primary endpoints will be the proportion of women in each group who remain euthyroid throughout the first trimester and throughout pregnancy.
NCT01832753 ↗	Treatment Trial of Subclinical Hypothyroidism in Down Syndrome	Completed	Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	N/A	2013-01-01	The purpose of this research study is to learn about the effects of treating subclinical hypothyroidism (SCH) with thyroid hormone replacement in children and adolescents with Down syndrome (DS). We hypothesize that treatment of SCH with thyroid hormone replacement will improve cardiometabolic health and quality of life.
NCT01832753 ↗	Treatment Trial of Subclinical Hypothyroidism in Down Syndrome	Completed	Children's Hospital of Philadelphia	N/A	2013-01-01	The purpose of this research study is to learn about the effects of treating subclinical hypothyroidism (SCH) with thyroid hormone replacement in children and adolescents with Down syndrome (DS). We hypothesize that treatment of SCH with thyroid hormone replacement will improve cardiometabolic health and quality of life.

Clinical Trial Conditions for UNITHROID

Condition Name

Condition Name for UNITHROID
Intervention	Trials
Down Syndrome	1
Hypothyroidism	1
Pregnancy	1
Subclinical Hypothyroidism	1

Condition MeSH

Condition MeSH for UNITHROID
Intervention	Trials
Hypothyroidism	2
Down Syndrome	1
Syndrome	1

Clinical Trial Locations for UNITHROID

Trials by Country

Trials by Country for UNITHROID
Location	Trials
United States	3

Trials by US State

Trials by US State for UNITHROID
Location	Trials
Pennsylvania	1
District of Columbia	1
Massachusetts	1

Clinical Trial Progress for UNITHROID

Clinical Trial Phase

Clinical Trial Phase for UNITHROID
Clinical Trial Phase	Trials
N/A	2

Clinical Trial Status

Clinical Trial Status for UNITHROID
Clinical Trial Phase	Trials
Completed	2

Clinical Trial Sponsors for UNITHROID

Sponsor Name

Sponsor Name for UNITHROID
Sponsor	Trials
Harvard Medical School	1
Harvard Medical School (HMS and HSDM)	1
Harvard University	1

Sponsor Type

Sponsor Type for UNITHROID
Sponsor	Trials
Other	5
NIH	1