You're using a free limited version of DrugPatentWatch: Upgrade for Complete Access

Last Updated: November 2, 2024

CLINICAL TRIALS PROFILE FOR VYTORIN


✉ Email this page to a colleague

« Back to Dashboard


All Clinical Trials for VYTORIN

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00166504 ↗ Ezetimibe Plus (+) Simvastatin Versus Atorvastatin Comparative Study (0653A-092)(COMPLETED) Completed Merck Sharp & Dohme Corp. Phase 4 2005-10-01 This is an efficacy and safety study of Vytorin (ezetimibe (+) simvastatin) compared to atorvastatin (ezetimibe/simvastatin) at week 6 in primary hypercholesterolemia patients in Korea. The primary hypothesis being tested is that daily administration of Vytorin will result in a greater reduction of low density lipoprotein cholesterol (LDL-C) concentration from baseline after 6 weeks treatment compared to atorvastatin.
NCT00202878 ↗ IMPROVE-IT: Examining Outcomes in Subjects With Acute Coronary Syndrome: Vytorin (Ezetimibe/Simvastatin) vs Simvastatin (P04103) Completed Merck Sharp & Dohme Corp. Phase 3 2005-10-17 This is a randomized, active-control, double-blind study of subjects with stabilized high-risk acute coronary syndrome (ACS). The primary objective is to evaluate the clinical benefit of Ezetimibe/Simvastatin Combination 10/40 (single tablet, under the brand VYTORIN in the United States) compared with Simvastatin 40 mg. As per the original protocol, if low-density lipoprotein cholesterol (LDL-C) response was inadequate, the dose of simvastatin in the VYTORIN arm or simvastatin arm, could be increased to 80 mg (Note: per June 2011 protocol amendment, criteria for continued use of 80 mg simvastatin were modified and new increases of simvastatin dose to 80 mg were stopped). Clinical benefit will be defined as the reduction in the risk of the occurrence of the composite endpoint of cardiovascular (CV) death, major coronary events, and stroke.
NCT00395603 ↗ Vytorin Treating Uncontrolled Lipids (VyTUL) Study (0653A-122) Terminated Merck Sharp & Dohme Corp. Phase 3 2006-09-01 To compare the effectiveness of ezetimibe/simvastatin 10/40 daily to atorvastatin 80 daily in reducing the concentration of ldl-c at endpoint after 6 weeks of treatment.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for VYTORIN

Condition Name

Condition Name for VYTORIN
Intervention Trials
Hypercholesterolemia 15
Hyperlipidemia 4
Myocardial Infarction 3
[disabled in preview] 0
This preview shows a limited data set
Subscribe for full access, or try a Trial

Condition MeSH

Condition MeSH for VYTORIN
Intervention Trials
Hypercholesterolemia 15
Dyslipidemias 6
Hyperlipidemias 5
[disabled in preview] 0
This preview shows a limited data set
Subscribe for full access, or try a Trial

Clinical Trial Locations for VYTORIN

Trials by Country

Trials by Country for VYTORIN
Location Trials
United States 10
Korea, Republic of 6
Brazil 5
United Kingdom 1
Taiwan 1
This preview shows a limited data set
Subscribe for full access, or try a Trial

Trials by US State

Trials by US State for VYTORIN
Location Trials
New York 3
Maryland 1
Virginia 1
Colorado 1
Michigan 1
This preview shows a limited data set
Subscribe for full access, or try a Trial

Clinical Trial Progress for VYTORIN

Clinical Trial Phase

Clinical Trial Phase for VYTORIN
Clinical Trial Phase Trials
Phase 4 18
Phase 3 12
Phase 2/Phase 3 1
[disabled in preview] 0
This preview shows a limited data set
Subscribe for full access, or try a Trial

Clinical Trial Status

Clinical Trial Status for VYTORIN
Clinical Trial Phase Trials
Completed 30
Unknown status 3
Not yet recruiting 2
[disabled in preview] 0
This preview shows a limited data set
Subscribe for full access, or try a Trial

Clinical Trial Sponsors for VYTORIN

Sponsor Name

Sponsor Name for VYTORIN
Sponsor Trials
Merck Sharp & Dohme Corp. 22
Gachon University Gil Medical Center 2
Fundación Lindavista del Corazón AC 1
[disabled in preview] 0
This preview shows a limited data set
Subscribe for full access, or try a Trial

Sponsor Type

Sponsor Type for VYTORIN
Sponsor Trials
Other 26
Industry 25
NIH 3
[disabled in preview] 0
This preview shows a limited data set
Subscribe for full access, or try a Trial

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.