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Last Updated: November 22, 2024

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CLINICAL TRIALS PROFILE FOR XALKORI


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All Clinical Trials for XALKORI

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00939770 ↗ Crizotinib in Treating Younger Patients With Relapsed or Refractory Solid Tumors or Anaplastic Large Cell Lymphoma Completed National Cancer Institute (NCI) Phase 1/Phase 2 2009-09-21 This phase 1/2 trial the studies side effects and best dose of crizotinib and to see how well it works in treating young patients with solid tumors or anaplastic large cell lymphoma that has returned after a period of improvement or does not respond to treatment. Crizotinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. (Phase 1 completed 2/15/13)
NCT00939770 ↗ Crizotinib in Treating Younger Patients With Relapsed or Refractory Solid Tumors or Anaplastic Large Cell Lymphoma Completed Pfizer Phase 1/Phase 2 2009-09-21 This phase 1/2 trial the studies side effects and best dose of crizotinib and to see how well it works in treating young patients with solid tumors or anaplastic large cell lymphoma that has returned after a period of improvement or does not respond to treatment. Crizotinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. (Phase 1 completed 2/15/13)
NCT00939770 ↗ Crizotinib in Treating Younger Patients With Relapsed or Refractory Solid Tumors or Anaplastic Large Cell Lymphoma Completed Children's Oncology Group Phase 1/Phase 2 2009-09-21 This phase 1/2 trial the studies side effects and best dose of crizotinib and to see how well it works in treating young patients with solid tumors or anaplastic large cell lymphoma that has returned after a period of improvement or does not respond to treatment. Crizotinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. (Phase 1 completed 2/15/13)
NCT01531361 ↗ Vemurafenib With Sorafenib Tosylate or Crizotinib in Treating Patients With Advanced Malignancies With BRAF Mutations Completed National Cancer Institute (NCI) Phase 1 2012-02-06 This phase I clinical trial studies vemurafenib with sorafenib tosylate or crizotinib in treating patients with advanced malignancies with BRAF mutations. Sorafenib tosylate and crizotinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Sorafenib tosylate may also stop the growth of advanced malignancies by blocking blood flow to tumors. Drugs used in chemotherapy, such as vemurafenib, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving vemurafenib together with sorafenib tosylate or crizotinib may kill more cancer cells.
NCT01531361 ↗ Vemurafenib With Sorafenib Tosylate or Crizotinib in Treating Patients With Advanced Malignancies With BRAF Mutations Completed M.D. Anderson Cancer Center Phase 1 2012-02-06 This phase I clinical trial studies vemurafenib with sorafenib tosylate or crizotinib in treating patients with advanced malignancies with BRAF mutations. Sorafenib tosylate and crizotinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Sorafenib tosylate may also stop the growth of advanced malignancies by blocking blood flow to tumors. Drugs used in chemotherapy, such as vemurafenib, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving vemurafenib together with sorafenib tosylate or crizotinib may kill more cancer cells.
NCT01548144 ↗ Pazopanib or Pemetrexed and Crizotinib in Advanced Cancer Terminated M.D. Anderson Cancer Center Phase 1 2012-04-01 The goal of this clinical research study is to find the highest tolerable dose of the combination of Xalkori (crizotinib) either with Votrient (pazopanib) or Alimta (pemetrexed) or of the combination of 3 study drugs that can be given to patients with advanced cancer. The safety of these drug combinations will also be studied. Crizotinib is designed to block a protein called ALK, which is involved in cancer cell growth and survival. Pazopanib is designed to block the growth of blood vessels that supply nutrients needed for tumor growth. This may prevent or slow the growth of cancer cells. Pemetrexed is designed to block proteins that may cause tumors to grow. This is an investigational study. Crizotinib is FDA approved and commercially available for the treatment of locally advanced or metastatic non-small cell lung cancer. Pazopanib is FDA approved and commercially available for treatment of advanced renal cell carcinoma. Pemetrexed is FDA approved and commercially available for the treatment of non-small cell lung cancer. The combination of crizotinib with pazopanib, crizotinib with pemetrexed, pazopanib with pemetrexed, and giving all 3 drugs together to patients with advanced cancer is investigational. Up to 364 patients will take part in this study. All will be enrolled at MD Anderson.
NCT01597258 ↗ Safety And Efficacy Of Crizotinib (Regulatory Post Marketing Commitment Plan) Completed Pfizer 2012-05-29 The objective of this surveillance is to collect information about 1) adverse drug reaction not expected from the LPD (unknown adverse drug reaction), 2) the incidence of adverse drug reactions in this surveillance, and 3)factors considered to affect the safety and/or efficacy of this drug.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for XALKORI

Condition Name

Condition Name for XALKORI
Intervention Trials
Carcinoma, Non-Small-Cell Lung 5
Advanced Malignant Solid Neoplasm 4
Refractory Malignant Solid Neoplasm 4
Non-small Cell Lung Cancer 4
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Condition MeSH

Condition MeSH for XALKORI
Intervention Trials
Carcinoma, Non-Small-Cell Lung 20
Lung Neoplasms 16
Neoplasms 12
Lymphoma 7
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Clinical Trial Locations for XALKORI

Trials by Country

Trials by Country for XALKORI
Location Trials
United States 566
China 69
Japan 36
Canada 29
Italy 28
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Trials by US State

Trials by US State for XALKORI
Location Trials
Texas 21
New York 21
Pennsylvania 19
Florida 18
California 18
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Clinical Trial Progress for XALKORI

Clinical Trial Phase

Clinical Trial Phase for XALKORI
Clinical Trial Phase Trials
Phase 4 2
Phase 3 7
Phase 2/Phase 3 3
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Clinical Trial Status

Clinical Trial Status for XALKORI
Clinical Trial Phase Trials
Recruiting 19
Active, not recruiting 11
Completed 9
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Clinical Trial Sponsors for XALKORI

Sponsor Name

Sponsor Name for XALKORI
Sponsor Trials
Pfizer 23
National Cancer Institute (NCI) 14
M.D. Anderson Cancer Center 4
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Sponsor Type

Sponsor Type for XALKORI
Sponsor Trials
Industry 62
Other 43
NIH 14
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