CLINICAL TRIALS PROFILE FOR ZESTRIL

All Clinical Trials for ZESTRIL

Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
NCT00347360 ↗	The COREG And Lisinopril Combination Therapy In Hypertensive Subjects (COSMOS) Trial	Completed	GlaxoSmithKline	Phase 3	2006-07-01	This is a randomized, double-blind, double-dummy, parallel group trial employing 15 cells of a 4x4 factorial design (no placebo)to compare the hypertensive effects in patients with Stage 1 and Stage 2 hypertension of carvedilol (20, 40 or 80 mg daily) alone, lisinopril (10, 20 or 40 mg daily) alone, and all combinations of the doses.
NCT00552708 ↗	A Study Investigating the Bioequivalence of the Fixed Dose Combination of COREG CR to COREG CR and ZESTRIL.	Completed	GlaxoSmithKline	Phase 1	2007-09-01	This study will be a randomized study investigating the bioequivalence of COREG CR to its components, COREG and Lisinopril (ZESTRIL). PK samples will be obtained throughout the study to investigate the PK of COREG CR FDC to COREG and Lisinopril
NCT00556920 ↗	Study to Demonstrate the Bioequivalence of the Fixed Dose Combination of COREG CR™ and Lisinopril to Its Components	Completed	GlaxoSmithKline	Phase 1	2007-10-01	This study will be a randomized study investigating the bioequivalence of COREG CR and Lisinopril to COREG CR and ZESTRIL
NCT00883064 ↗	To Demonstrate the Relative Bioequivalence of Lisinopril 1 x 40 mg Tablets Under Fasting Conditions	Completed	Sandoz	Phase 1	2000-03-01	To Demonstrate the Relative Bioequivalence of Lisinopril 1 x 40 mg Tablets Under Fasting Conditions.
NCT00883506 ↗	To Demonstrate the Relative Bioequivalence of Lisinopril 1 x 40 mg Tablet Under Fasting and Fed	Completed	Sandoz	Phase 1	2000-05-01	To Demonstrate the Relative Bioequivalence of Lisinopril 1 x 40 mg Tablet under Fasting and Fed.
NCT01234922 ↗	Benazepril Hydrochloride, Lisinopril, Ramipril, or Losartan Potassium in Treating Hypertension in Patients With Solid Tumors	Terminated	Comprehensive Cancer Center of Wake Forest University	Phase 2	2011-02-01	RATIONALE: Benazepril hydrochloride, lisinopril, ramipril, and losartan potassium may help lower blood pressure. PURPOSE: This phase II trial is studying how well benazepril hydrochloride, lisinopril, ramipril, or losartan potassium works in treating hypertension in patients with solid tumors.
NCT01234922 ↗	Benazepril Hydrochloride, Lisinopril, Ramipril, or Losartan Potassium in Treating Hypertension in Patients With Solid Tumors	Terminated	Wake Forest University Health Sciences	Phase 2	2011-02-01	RATIONALE: Benazepril hydrochloride, lisinopril, ramipril, and losartan potassium may help lower blood pressure. PURPOSE: This phase II trial is studying how well benazepril hydrochloride, lisinopril, ramipril, or losartan potassium works in treating hypertension in patients with solid tumors.

Clinical Trial Conditions for ZESTRIL

Condition Name

Condition Name for ZESTRIL
Intervention	Trials
Hypertension	10
Healthy	4
Hypotension on Induction	1
Diabetes	1

Condition MeSH

Condition MeSH for ZESTRIL
Intervention	Trials
Hypertension	9
Malnutrition	2
Lung Neoplasms	1
Leukemia, Lymphoid	1

Clinical Trial Locations for ZESTRIL

Trials by Country

Trials by Country for ZESTRIL
Location	Trials
United States	54
India	2
Indonesia	1
Sweden	1
France	1

Trials by US State

Trials by US State for ZESTRIL
Location	Trials
California	4
Minnesota	4
North Carolina	3
New York	3
Nebraska	3

Clinical Trial Progress for ZESTRIL

Clinical Trial Phase

Clinical Trial Phase for ZESTRIL
Clinical Trial Phase	Trials
Phase 4	2
Phase 3	1
Phase 2	6

Clinical Trial Status

Clinical Trial Status for ZESTRIL
Clinical Trial Phase	Trials
Completed	16
Recruiting	3
Unknown status	2

Clinical Trial Sponsors for ZESTRIL

Sponsor Name

Sponsor Name for ZESTRIL
Sponsor	Trials
National Cancer Institute (NCI)	3
GlaxoSmithKline	3
PharmaKinetics Laboratories Inc.	2

Sponsor Type

Sponsor Type for ZESTRIL
Sponsor	Trials
Industry	17
Other	11
NIH	5