The Safety and Effectiveness of Zidovudine Plus Acyclovir in Patients With Early HIV Infection
Completed
Glaxo Wellcome
N/A
1969-12-31
This double-blind, placebo-controlled study is designed to determine the long-term safety and
efficacy of concurrent oral Retrovir / Zovirax (AZT and ACV) therapy and oral AZT therapy
alone, in the treatment of early symptomatic HIV infection. Efficacy will be evaluated by
monitoring the incidence, severity, and time of development of opportunistic infections and
other manifestations of advanced symptomatic HIV infection. The effects of the combination
and single AZT therapy on immune function and viral replication will also be evaluated. Study
participants will be monitored for evidence of toxicity or intolerance to concurrent AZT /
ACV administration and AZT therapy alone.
Effectiveness of Acyclovir in Suppressing HIV Viral Load in Women Coinfected With HIV and Herpes Simplex Virus Type 2 (HSV-2)
Completed
Comprehensive International Program of Research on AIDS
Phase 2
2006-09-01
The purpose of this study is to determine whether acyclovir is effective in suppressing HIV
viral load in women infected with both HIV-1 and herpes simplex virus type 2 (HSV-2) who are
starting HIV treatment for the first time.
Effectiveness of Acyclovir in Suppressing HIV Viral Load in Women Coinfected With HIV and Herpes Simplex Virus Type 2 (HSV-2)
Completed
National Institute of Allergy and Infectious Diseases (NIAID)
Phase 2
2006-09-01
The purpose of this study is to determine whether acyclovir is effective in suppressing HIV
viral load in women infected with both HIV-1 and herpes simplex virus type 2 (HSV-2) who are
starting HIV treatment for the first time.
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