Tailored Treatment of H. Pylori Infection Based Polymorphisms of CYP2C19 and 23S rRNA of H. Pylori
Unknown status
Yokoyama Foundation for Clinical Pharmacology
Phase 3
2003-04-01
The eradication rate of the standard H. pylori eradication therapy (such as the triple
therapy with a proton pump inhibitor [PPI], amoxicillin and clarithromycin) depends on
bacterial susceptibility to clarithromycin and genotypes of CYP2C19 in patients. The
investigators intend to investigate whether the tailored therapy based on the two
above-mentioned factors increases the cure rate of the initial eradication therapy.
Tailored Treatment of H. Pylori Infection Based Polymorphisms of CYP2C19 and 23S rRNA of H. Pylori
Unknown status
Hamamatsu University
Phase 3
2003-04-01
The eradication rate of the standard H. pylori eradication therapy (such as the triple
therapy with a proton pump inhibitor [PPI], amoxicillin and clarithromycin) depends on
bacterial susceptibility to clarithromycin and genotypes of CYP2C19 in patients. The
investigators intend to investigate whether the tailored therapy based on the two
above-mentioned factors increases the cure rate of the initial eradication therapy.
The Influence of FP-10 on the Eradication Rates of H. Pylori by a Triple Therapy
Unknown status
Oita University
Phase 2/Phase 3
2006-01-01
FP-10 is a food ingredient derived from milk casein. FP-10 can inhibit H. pylori to attach to
the gastric epithelium. FP-10 has been made clear to decrease the intragastric urease
activity (which is assumed to be produced by H. pylori) measured by the urea breath test.
FP-10 can also detach H. pylori from gastric epithelium. We have hypothesized that FP-10
increases the eradication rates by a triple therapy with a proton pump inhibitor,
amoxicillin, and clarithromycin.
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