A Trial of Belzutifan (PT2977, MK-6482) Tablets In Patients With Advanced Solid Tumors (MK-6482-001)
Active, not recruiting
Peloton Therapeutics, Inc.
Phase 1
2016-12-07
The primary objective of this study is to identify the maximum tolerated dose (MTD) of
belzutifan Tablets and/or the recommended Phase 2 dose (RP2D) of belzutifan Tablets in
patients with advanced solid tumors
A Phase 2 Study of Belzutifan (PT2977, MK-6482) for the Treatment of Von Hippel Lindau (VHL) Disease-Associated Renal Cell Carcinoma (RCC) (MK-6482-004)
Active, not recruiting
Peloton Therapeutics, Inc.
Phase 2
2018-05-02
This study is designed to investigate belzutifan as a treatment for VHL disease associated
RCC.
A Food Effect Study in Healthy Volunteers With Belzutifan (PT2977, MK-6482) Tablets
Completed
Peloton Therapeutics, Inc.
Phase 1
2018-02-23
This Phase 1, single-dose study will be conducted in adult male and female subjects (N = 16)
who are in general good health and selected for participation in the study according to the
selection criteria. This study will assess the effect of food on the pharmacokinetics of
belzutifan Tablets. The study will consist of two periods and will be conducted in a
crossover fashion.
A Trial of Belzutifan (PT2977, MK-6482) in Combination With Cabozantinib in Patients With Clear Cell Renal Cell Carcinoma (ccRCC) (MK-6482-003)
Recruiting
Peloton Therapeutics, Inc.
Phase 2
2018-09-27
This is an open-label Phase 2 study which will evaluate the efficacy and safety of belzutifan
in combination with cabozantinib in participants with advanced ccRCC. Belzutifan and
cabozantinib will be administered orally once daily.
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