Factor Xa Inhibitor, PRT054021, Against Enoxaparin for the Prevention of Venous Thromboembolic Events (EXPERT)
Completed
Portola Pharmaceuticals
Phase 2
2006-05-01
Randomized study of PRT054021 40 mg and 15 mg bid vs. enoxaparin 30 mg q12h for the
prophylaxis of venous thromboembolic events after unilateral knee replacement surgery.
Phase 2 Study of the Safety, Tolerability and Pilot Efficacy of Oral Factor Xa Inhibitor Betrixaban Compared to Warfarin
Completed
Portola Pharmaceuticals
Phase 2
2008-10-01
Prevention of stroke in patients with atrial fibrillation (AF). Hypothesis: In patients with
non-valvular AF, orally administered betrixaban will provide similar or better efficacy and
safety than warfarin and it will offer the advantage of not requiring dose adjustments due to
international normalized ratios (INRs) outside the target range of 2.0 to 3.0 and a more
consistent level of anticoagulation over time.
A Study to Determine the Pharmacokinetics, Pharmacodynamics, and Tolerabiltiy of Betrixaban in Patients With Mild, Moderate, and Severe Renal Impairment
Completed
Merck Sharp & Dohme Corp.
Phase 1
2009-07-01
The purpose of the study is to compare the pharmacokinetics, pharmacodynamics, and
tolerability of betrixaban in patients with mild, moderate, and severe renal impairment to
healthy volunteers.
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