Study of Bile Acids in Patients With Peroxisomal Disorders
Terminated
Children's Hospital Medical Center, Cincinnati
N/A
1969-12-31
OBJECTIVES: I. Determine the effectiveness of oral bile acid therapy with cholic acid,
chenodeoxycholic acid, and ursodeoxycholic acid in patients with peroxisomal disorders
involving impaired primary bile acid synthesis.
II. Determine whether suppression of synthesis of atypical bile acids and enrichment of bile
acid pool with this regimen is effective in treating this patient population and improving
quality of life.
Study of Bile Acids in Patients With Peroxisomal Disorders
Terminated
University of Cincinnati
N/A
1969-12-31
OBJECTIVES: I. Determine the effectiveness of oral bile acid therapy with cholic acid,
chenodeoxycholic acid, and ursodeoxycholic acid in patients with peroxisomal disorders
involving impaired primary bile acid synthesis.
II. Determine whether suppression of synthesis of atypical bile acids and enrichment of bile
acid pool with this regimen is effective in treating this patient population and improving
quality of life.
Compassionate Treatment of Patients With Inborn Errors of Bile Acid Metabolism With Cholic Acid
Completed
Children's Hospital Medical Center, Cincinnati
Phase 3
1992-01-01
OBJECTIVES:
I. To Evaluate the therapeutic efficacy of cholic acid during provision of compassionate
treatment to patients with identified inborn errors of bile acid synthesis and metabolism
II. To assess the safety and tolerability of cholic acid
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