This study will establish a network of interactive asthma clinical research groups to
evaluate current therapies, new therapies, and management strategies for adult asthma.
This study will establish a network of interactive asthma clinical research groups to
evaluate current therapies, new therapies, and management strategies for adult asthma.
Phase I Study of Colchicine Therapy in Childhood Hepatic Cirrhosis
Unknown status
Children's Hospital Colorado
Phase 1
1990-05-01
OBJECTIVES:
I. Investigate the efficacy and safety of colchicine therapy in improving hepatic function
and reducing hepatic fibrosis (scarring) in children with hepatic cirrhosis.
Phase I Study of Colchicine Therapy in Childhood Hepatic Cirrhosis
Unknown status
National Center for Research Resources (NCRR)
Phase 1
1990-05-01
OBJECTIVES:
I. Investigate the efficacy and safety of colchicine therapy in improving hepatic function
and reducing hepatic fibrosis (scarring) in children with hepatic cirrhosis.
Low-Dose Oral Methotrexate Versus Colchicine for Primary Biliary Cirrhosis
Completed
Tufts Medical Center
Phase 3
1989-11-01
OBJECTIVES:
I. Compare the efficacy of low-dose oral pulse methotrexate (MTX) and ursodiol versus
colchicine and ursodiol in patients with primary biliary cirrhosis (PBC).
II. Determine the optimum dose and duration of MTX treatment.
III. Investigate the role of fibrogenic cytokines (FC) in PBC pathogenesis and the effect of
treatment on FC production.
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