CLINICAL TRIALS PROFILE FOR CYCLOPENTOLATE HYDROCHLORIDE; PHENYLEPHRINE HYDROCHLORIDE
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All Clinical Trials for cyclopentolate hydrochloride; phenylephrine hydrochloride
| Trial ID | Title | Status | Sponsor | Phase | Start Date | Summary |
|---|---|---|---|---|---|---|
| NCT01170130 ↗ | Lidocaine Usage for Pupil Dilatation (Mydriasis) | Completed | Carmel Medical Center | N/A | 2009-12-01 | The purpose of this study is to determine if the mydriatic effect of intracameral lidocaine 1% is as effective as topical cyclopentolate 1% and phenylephrine 10% for achieving effective mydriasis during phacoemulsification surgery. |
| NCT02177539 ↗ | A New More Efficient Cycloplegia Scheme | Unknown status | Pontificia Universidad Catolica de Chile | Phase 4 | 2014-05-01 | The purpose of this study is to determine whether tropicamide + phenylephrine cyclopentolate + applied for once waiting 30 minutes to retinoscopy (new scheme) is not inferior to apply cyclopentolate alone and wait 45 minutes to retinoscopy (traditional scheme) |
| NCT02895035 ↗ | Comparison of Epinephrine and Phenylephrine/Ketorolac With Regards to Pupil Size | Terminated | Milton S. Hershey Medical Center | Phase 4 | 2016-09-01 | The objective of this study is to compare the maintenance of intraoperative mydriasis during cataract surgery between two drugs: epinephrine, which has routinely been used for decades, and Omidria, a newly FDA approved combination drug of phenylephrine and ketorolac. Patients undergoing cataract surgery that are enrolled in the trial will randomly receive one of the drugs in one eye, and the other eye will receive the drug during the subsequent cataract surgery. |
| NCT04838665 ↗ | Changes in Vital Signs and Pupil Diameter Related to Pharmacologic Mydriasis in Premature Infants: A Randomized Double Blind Clinical Study | Completed | University of the Philippines | Phase 4 | 2011-09-30 | Retinopathy of prematurity (ROP) is one of the common anatomic causes of blindness among Filipinos, accounting for 47.7% of the cases. With this retinopathy being preventable and treatable, ROP screening has been proven to be effective in preventing blindness, which is achieved with the usage of mydriatics. Even if the regimen of multiple alternate instillations of 0.5% tropicamide and 2.5% phenylephrine is the one recommended by international guidelines for ROP screening, the mydriatic regimen used by many of the country's institutions is the single instillation of 0.5% tropicamide + 0.5% phenylephrine applied via a cotton wick placed in the inferior fornix (SIW). There have been no studies yet on the safety and efficacy in premature infants of this mydriatic preparation and method, although it is hypothesized that the usage of a cotton wick promotes the possible systemic effects of the mydriatic combination used. This study then aims to determine the safety and efficacy of different mydriatic regimens in premature infants referred for screening of ROP using (1) multiple alternate instillations of 0.5% cyclopentolate hydrochloride and 2.5% phenylephrine (MAI), (2) single instillation of 0.5% tropicamide + 0.5% phenylephrine (SI), and (3) single instillation of 0.5% tropicamide + 0.5% phenylephrine with a cotton wick placed in the inferior fornix (SIW) in a tertiary Philippine hospital. This study was designed as a randomized, double blind, clinical study which enrolled sixty preterm infants referred for ROP Screening from January to July 2011. With instillations via MAI, SI, and SIW, systolic blood pressure (SBP), diastolic pressure (DBP), mean arterial pressure (MAP), heart rate, and oxygen saturation were monitored from ten minutes prior to instillation up to forty-five minutes after instillation. Pupil dilations were also measured at the forty-fifth minute. |
| >Trial ID | >Title | >Status | >Sponsor | >Phase | >Start Date | >Summary |
Clinical Trial Conditions for cyclopentolate hydrochloride; phenylephrine hydrochloride
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Clinical Trial Locations for cyclopentolate hydrochloride; phenylephrine hydrochloride
Clinical Trial Progress for cyclopentolate hydrochloride; phenylephrine hydrochloride
Clinical Trial Phase
Clinical Trial Sponsors for cyclopentolate hydrochloride; phenylephrine hydrochloride
Sponsor Name
| Sponsor Name for cyclopentolate hydrochloride; phenylephrine hydrochloride | |
| Sponsor | Trials |
| Pontificia Universidad Catolica de Chile | 1 |
| Milton S. Hershey Medical Center | 1 |
| University of the Philippines | 1 |
| [disabled in preview] | 1 |
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