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Last Updated: November 22, 2024

CLINICAL TRIALS PROFILE FOR CYPROHEPTADINE HYDROCHLORIDE


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All Clinical Trials for cyproheptadine hydrochloride

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00066248 ↗ Cyproheptadine and Megestrol in Preventing Weight Loss in Children With Cachexia Caused By Cancer or Cancer Treatment Completed National Cancer Institute (NCI) Phase 2 2003-06-01 RATIONALE: Cyproheptadine and megestrol may improve appetite and help prevent weight loss in children with cancer. PURPOSE: This phase II trial is studying how well cyproheptadine and megestrol work in improving appetite and preventing weight loss in children with cachexia caused by cancer or cancer treatment.
NCT00066248 ↗ Cyproheptadine and Megestrol in Preventing Weight Loss in Children With Cachexia Caused By Cancer or Cancer Treatment Completed University of South Florida Phase 2 2003-06-01 RATIONALE: Cyproheptadine and megestrol may improve appetite and help prevent weight loss in children with cancer. PURPOSE: This phase II trial is studying how well cyproheptadine and megestrol work in improving appetite and preventing weight loss in children with cachexia caused by cancer or cancer treatment.
NCT00108420 ↗ Prazosin Treatment for Combat Trauma PTSD (Post-Traumatic Stress Disorder) Nightmares and Sleep Disturbance Completed US Department of Veterans Affairs Phase 4 2003-10-01 The purpose of this study is to determine whether prazosin will reduce the incidence of nightmares, sleep disturbance, and overall symptoms in combat trauma-exposed individuals with PTSD.
NCT00108420 ↗ Prazosin Treatment for Combat Trauma PTSD (Post-Traumatic Stress Disorder) Nightmares and Sleep Disturbance Completed VA Office of Research and Development Phase 4 2003-10-01 The purpose of this study is to determine whether prazosin will reduce the incidence of nightmares, sleep disturbance, and overall symptoms in combat trauma-exposed individuals with PTSD.
NCT00286988 ↗ Topiramate for the Prophylactic Treatment of Cyclic Vomiting Syndrome in Children Terminated Ortho-McNeil Neurologics, Inc. Phase 4 2006-03-01 The purpose of this study is to assess the effectiveness, tolerability and safety of oral topiramate for the preventative management of Cyclic Vomiting Syndrome. It is believed that topiramate will decrease the frequency, duration and severity of attacks experienced by children and adolescents with Cyclic Vomiting Syndrome.
NCT00286988 ↗ Topiramate for the Prophylactic Treatment of Cyclic Vomiting Syndrome in Children Terminated Monarch Medical Research Phase 4 2006-03-01 The purpose of this study is to assess the effectiveness, tolerability and safety of oral topiramate for the preventative management of Cyclic Vomiting Syndrome. It is believed that topiramate will decrease the frequency, duration and severity of attacks experienced by children and adolescents with Cyclic Vomiting Syndrome.
NCT00746785 ↗ A New Pharmacotherapy for Alcohol Dependence: Olanzapine Completed The Mind Research Network Phase 3 2002-09-01 Craving for alcohol has been related to loss of control drinking and is a major target of biological and behavioral interventions for alcohol dependence. Our previous research has demonstrated that olanzapine (a dopamine antagonist) attenuates craving for alcohol, that a variant in the gene that expresses D4 receptors influences craving for alcohol, and that olanzapine is particularly effective at reducing craving among individuals with this variant. Pilot data from a recent 12 week trial of olanzapine indicates that olanzapine is well tolerated and that olanzapine reduces drinking, particularly among individuals with the aforementioned genetic variant. The objective of the present application is to examine the effectiveness of olanzapine (5 mg/day), as compared to olanzapine (2.5 mg/day) and a placebo control, in terms of reducing craving and alcohol use behavior among treatment seeking alcoholics. Furthermore, the present application will examine whether the effects of olanzapine on drinking outcomes are mediated by its effects on a specific putative mechanism (i.e., cue-elicited craving for alcohol) and determine whether the DRD4 VNTR polymorphism is a marker for the effectiveness of olanzapine. To that end, 202 alcohol dependent subjects will be randomly assigned to medication group and receive 12 weeks of medication. Subjects will complete follow-up assessments at 3 and 6 months after the end of the treatment. It is expected that olanzapine will significantly reduce cue-elicited craving and alcohol use behavior in a dose dependent fashion over the course of the 12 week trial and follow-up period, as compared to the placebo condition. Furthermore, it is expected that the effects of olanzapine on alcohol use behavior will be mediated by the effect of olanzapine on cue-elicited craving and that the effects of olanzapine on cue-elicited craving and alcohol use behavior will be moderated by the DRD4 VNTR, such that olanzapine will be more effective among individuals with the 7 repeat allele. The successful completion of the proposed research is expected to advance a new medication for alcohol dependence and advance genetic markers that predict the effectiveness of this medication.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for cyproheptadine hydrochloride

Condition Name

Condition Name for cyproheptadine hydrochloride
Intervention Trials
Myelodysplastic Syndromes 2
Unspecified Childhood Solid Tumor, Protocol Specific 2
Viral Pneumonia 2
Leukemia 2
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Condition MeSH

Condition MeSH for cyproheptadine hydrochloride
Intervention Trials
COVID-19 4
Alcoholism 4
Pneumonia 3
Spinal Cord Injuries 3
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Clinical Trial Locations for cyproheptadine hydrochloride

Trials by Country

Trials by Country for cyproheptadine hydrochloride
Location Trials
United States 45
Brazil 3
Canada 2
France 1
India 1
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Trials by US State

Trials by US State for cyproheptadine hydrochloride
Location Trials
Illinois 3
Virginia 3
New York 3
California 3
Wisconsin 2
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Clinical Trial Progress for cyproheptadine hydrochloride

Clinical Trial Phase

Clinical Trial Phase for cyproheptadine hydrochloride
Clinical Trial Phase Trials
Phase 4 7
Phase 3 6
Phase 2/Phase 3 1
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Clinical Trial Status

Clinical Trial Status for cyproheptadine hydrochloride
Clinical Trial Phase Trials
Completed 9
Recruiting 5
Terminated 5
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Clinical Trial Sponsors for cyproheptadine hydrochloride

Sponsor Name

Sponsor Name for cyproheptadine hydrochloride
Sponsor Trials
National Cancer Institute (NCI) 3
University of South Florida 3
Rehabilitation Institute of Chicago 3
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Sponsor Type

Sponsor Type for cyproheptadine hydrochloride
Sponsor Trials
Other 44
NIH 7
Industry 3
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