Dacomitinib (PF-00299804) As A Single Oral Agent In Selected Patients With Adenocarcinoma Of The Lung
Completed
Pfizer
Phase 2
2009-03-11
This study will explore the safety and efficacy of the oral PanHER inhibitor PF-00299804 in
patients with adenocarcinoma of the lung who are either non-smokers (<100 cigarette, cigar or
pipe lifetime) or former light smokers ( less than 10 pack-years and stopped at least 15
years) or have known EGFR activating mutation; or patients with HER 2 amplification or
mutation.
ARCHER 1009 : A Study Of Dacomitinib (PF-00299804) Vs. Erlotinib In The Treatment Of Advanced Non-Small Cell Lung Cancer
Completed
Pfizer
Phase 3
2011-06-16
This is a multinational, multicenter, randomized,double-blinded, Phase 3 study comparing the
efficacy and safety of treatment with PF-00299804 to treatment with erlotinib in patients
with advanced non-small cell lung cancer, previously treated with at least one prior regimen.
Analyses of primary objective (Progression Free Survival) will be done in two co-primary
populations as defined in the protocol.
Study Of Dacomitinib (PF-00299804) In Advanced NSCLC Patients (Post Chemo Or Select First Line) To Evaluate Prophylactic Intervention On Derm And GI AEs And PRO
Completed
Pfizer
Phase 2
2011-12-26
To assess the impact of prophylactic treatment on the incidence of adverse events in advanced
NSCLC patients (post chemotherapy) treated with dacomitinib daily as a single agent. To
assess the impact of an interrupted dacomitinib dosing schedule in Cycle 1 on the incidence
of adverse events in first-line advanced NSCLC patients with an EGFR mutation (HER-1
mutation, HER-2 mutation or HER-2 amplification).
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