CLINICAL TRIALS PROFILE FOR DAPAGLIFLOZIN; METFORMIN HYDROCHLORIDE; SAXAGLIPTIN HYDROCHLORIDE
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All Clinical Trials for dapagliflozin; metformin hydrochloride; saxagliptin hydrochloride
| Trial ID | Title | Status | Sponsor | Phase | Start Date | Summary |
|---|---|---|---|---|---|---|
| NCT01606007 ↗ | Safety and Efficacy of Combination Saxagliptin & Dapagliflozin Added to Metformin to Treat Subjects With Type 2 Diabetes | Completed | AstraZeneca | Phase 3 | 2012-07-01 | The purpose of this study is to learn if a combination of BMS-477118 (Saxagliptin) and BMS -512148 (Dapagliflozin) added to Metformin can improve (decrease) Glycosylated Hemoglobin (Hemoglobin A1c) in patients with type 2 diabetes after 24 weeks of treatment. The safety of this treatment will also be studied. |
| NCT01619059 ↗ | Safety and Efficacy of Saxagliptin in Triple Therapy to Treat Subjects With Type 2 Diabetes | Completed | AstraZeneca | Phase 3 | 2012-06-01 | The purpose of this study is to learn if BMS-477118 (Saxagliptin) as part of a triple combination therapy can improve (decrease) hemoglobin A1c in patients with type 2 diabetes after 24 weeks of treatment compared to a 2 drug oral antidiabetic therapy. The safety of this treatment will also be studied. |
| NCT01646320 ↗ | Safety and Efficacy of Dapagliflozin in Triple Therapy to Treat Subjects With Type 2 Diabetes | Completed | AstraZeneca | Phase 3 | 2012-09-01 | The purpose of this study is to learn if BMS-512148 (Dapagliflozin) as part of a triple combination therapy can improve (decrease) hemoglobin A1c in patients with type 2 diabetes after 24 weeks of treatment compared to a 2 drug oral antidiabetic therapy. The safety of this treatment will also be studied. |
| NCT02284893 ↗ | Study to Evaluate the Efficacy and Safety of Saxagliptin Co-administered With Dapagliflozin in Combination With Metformin Compared to Sitagliptin in Combination With Metformin in Adult Patients With Type 2 Diabetes Who Have Inadequate Glycemic Contr | Completed | AstraZeneca | Phase 3 | 2014-09-09 | Study will evaluate if a combination of saxagliptin and dapagliflozin added concurrently to metformin in combination with diet and exercise is superior to sitagliptin added to metformin in combination with diet and exercise in reducing mean HbA1c over a treatment period of 26 weeks. |
| NCT02304081 ↗ | Saxagliptin in Combination With Dapagliflozin - Effects on Islet Cell Function | Completed | Prof. Dr. Thomas Forst | Phase 4 | 2015-01-01 | The purpose of this study is to evaluate alpha- and beta-cell function during combination treatment with saxagliptin in addition to dapagliflozin and metformin compared to placebo in addition to dapagliflozin and metformin in subjects with T2DM on stable metformin background therapy. |
| NCT02419612 ↗ | A 52-week International, Multicenter Trial With a Long -Term Extension to Evaluate Saxagliptin With Dapagliflozin in Combination With Metformin Compared to Glimepiride in Combination With Metformin in Type 2 Diabetes Who Have Inadequate Glycemic Con | Completed | AstraZeneca | Phase 3 | 2015-08-14 | This clincial trial is evaluating if the co-administration of saxagliptin and dapagliflozin, in addition to metformin, results in better glycemic control, as measured by HbA1c, over a treatment period of 52 weeks, compared to the addition of glimepiride to metformin in subjects with Type 2 Diabetes Mellitus who have inadequate glycemic control on Metformin Alone. We will compare the change from baseline in HbA1c achieved with saxagliptin, in co-administration with dapagliflozin, added to current background therapy with metformin compared to glimepiride added to current background therapy with metformin ≥1500 mg at Week 52. |
| NCT02471404 ↗ | Efficacy and Safety of Dapagliflozin and Dapagliflozin Plus Saxagliptin in Combination With Metformin in Type 2 Diabetes Patients Compared With Sulphonylurea | Completed | AstraZeneca | Phase 4 | 2015-09-21 | This study is being carried out to see if dapagliflozin and dapagliflozin plus saxagliptin as an addition to metformin is effective and safe in treating patients with type 2 diabetes when compared to glimepiride (sulphonylurea) as an addition to metformin treatment. |
| >Trial ID | >Title | >Status | >Sponsor | >Phase | >Start Date | >Summary |
Clinical Trial Conditions for dapagliflozin; metformin hydrochloride; saxagliptin hydrochloride
Condition Name
| Condition Name for dapagliflozin; metformin hydrochloride; saxagliptin hydrochloride | |
| Intervention | Trials |
| Type 2 Diabetes Mellitus | 7 |
| Type 2 Diabetes | 4 |
| Type2 Diabetes Mellitus | 4 |
| Diabetes Mellitus, Type 2 | 4 |
| [disabled in preview] | 0 |
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Condition MeSH
| Condition MeSH for dapagliflozin; metformin hydrochloride; saxagliptin hydrochloride | |
| Intervention | Trials |
| Diabetes Mellitus, Type 2 | 18 |
| Diabetes Mellitus | 18 |
| Cardiovascular Diseases | 1 |
| Prediabetic State | 1 |
| [disabled in preview] | 0 |
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Clinical Trial Locations for dapagliflozin; metformin hydrochloride; saxagliptin hydrochloride
Trials by Country
Clinical Trial Progress for dapagliflozin; metformin hydrochloride; saxagliptin hydrochloride
Clinical Trial Phase
Clinical Trial Sponsors for dapagliflozin; metformin hydrochloride; saxagliptin hydrochloride
Sponsor Name
| Sponsor Name for dapagliflozin; metformin hydrochloride; saxagliptin hydrochloride | |
| Sponsor | Trials |
| AstraZeneca | 15 |
| The University of Texas Health Science Center at San Antonio | 2 |
| Korea University Anam Hospital | 1 |
| [disabled in preview] | 4 |
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