Deoxycholic Acid Injection for the Treatment of Superficial Lipomas
Completed
Kythera Biopharmaceuticals
Phase 1
2007-01-01
The purpose of this research is to compare the safety and effectiveness of 4 different
concentrations of deoxycholic acid injection against a placebo in the treatment of
superficial lipomas.
Phase 2 Study for the Treatment of Superficial Lipomas
Completed
Kythera Biopharmaceuticals
Phase 2
2007-11-01
The purpose of this research is to compare the safety and effectiveness of 3 different
concentrations of deoxycholic acid for injection against a placebo in the treatment of
superficial lipomas.
Phase 2 Study of Deoxycholic Acid Injection (ATX-101) for the Reduction of Submental Fat
Completed
Kythera Biopharmaceuticals
Phase 2
2008-04-01
Phase 2 trial to evaluate the safety and potential efficacy of one concentration of
deoxycholic acid injection, given in three dosing paradigms, compared to placebo for the
reduction of submental fat (fat beneath the chin).
Phase 1-2 Study of Deoxycholic Acid Injection (ATX-101) for the Reduction of Submental Fat
Completed
Kythera Biopharmaceuticals
Phase 1/Phase 2
2007-08-01
To evaluate the safety and potential efficacy of deoxycholic acid injection compared to
placebo for the reduction of submental fat (fat below the chin).
Clinical Studies on Bile Acids in Barrett's Esophagus
Completed
US Department of Veterans Affairs
N/A
2009-03-01
This study has two major goals:
1. To determine the effects of bile salts on causing DNA injury and activating signaling
pathways that promote growth in cells from the esophagus of patients who have
gastroesophageal reflux disease (GERD)
2. To determine whether changes in bile composition induced by treating patients with a
bile salt called ursodeoxycholic acid (UDCA) can alter DNA injury, signaling pathway
activation and other types of damage in cells from the esophagus of patients who have
GERD.
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