Hormone Therapy and Chemotherapy in Treating Perimenopausal or Postmenopausal Women With Node-Positive Breast Cancer
Completed
International Breast Cancer Study Group
Phase 3
1993-05-01
RATIONALE: Estrogen can stimulate the growth of breast cancer cells. Hormone therapy may
fight breast cancer by blocking the uptake of estrogen. Drugs used in chemotherapy use
different ways to stop tumor cells from dividing so they stop growing or die. Combining
chemotherapy with hormone therapy may kill more tumor cells. It is not yet known which
treatment regimen is more effective for breast cancer.
PURPOSE: Randomized phase III trial to compare the effectiveness of hormone therapy during or
after combination chemotherapy or hormone therapy alone in treating perimenopausal or
postmenopausal women who have stage II or stage IIIA breast cancer.
Tamoxifen in Treating Women With High-Risk Breast Cancer
Completed
NCIC Clinical Trials Group
Phase 3
1993-07-20
RATIONALE: Estrogen can stimulate the growth of breast cancer cells. Hormone therapy using
tamoxifen may fight breast cancer by blocking the uptake of estrogen. Chemotherapy uses
different ways to stop tumor cells from dividing so they stop growing or die.
PURPOSE: Phase III trial to study the effectiveness of tamoxifen following surgery and
chemotherapy in treating women who have stage I breast cancer at high risk of recurrence or
stage II or stage III breast cancer.
Mitoxantrone With or Without Docetaxel in Treating Women With Metastatic Breast Cancer
Completed
Arbeitsgemeinschaft fur Internistische Onkologie
Phase 3
1993-05-01
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so
they stop growing or die. It is not yet known if mitoxantrone is more effective with or
without docetaxel.
PURPOSE: Randomized phase III trial to compare the effectiveness of mitoxantrone with or
without docetaxel in treating women who have metastatic breast cancer with a poor prognosis.
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