CLINICAL TRIALS PROFILE FOR ESKETAMINE HYDROCHLORIDE

All Clinical Trials for esketamine hydrochloride

Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
NCT00847418 ↗	Pharmacokinetics and Pharmacodynamics of Nasally Applied Esketamine	Completed	University Hospital, Basel, Switzerland	Phase 1	2009-02-01	The purpose of this study is the determination of blood concentration and the effectiveness of esketamine after nasal application.
NCT01640080 ↗	A Study of the Efficacy of Intravenous Esketamine in Adult Patients With Treatment-Resistant Depression	Completed	Janssen Research & Development, LLC	Phase 2	2012-06-27	The purpose of this study is to assess the efficacy of esketamine compared with placebo in improving symptoms of depression in patients with treatment resistant depression.
NCT01780259 ↗	A Study to Assess the Pharmacokinetics, Safety, and Tolerability of Intranasally Administered Esketamine in Healthy Participants	Completed	Janssen Research & Development, LLC	Phase 1	2012-12-01	The primary purpose of the study is to evaluate the pharmacokinetics (what the body does to the medication) of intranasally (through the nose) administered esketamine in healthy participants.
NCT01980303 ↗	A Study to Assess the Pharmacokinetics of Intranasally Administered Esketamine in Healthy Japanese and Caucasian Volunteers	Completed	Janssen Research & Development, LLC	Phase 1	2013-11-01	The purpose of this Phase 1 study is to characterize the pharmacokinetic profile (what the body does to the medication) of esketamine when given by the intranasal route (through the nose) to healthy adult Japanese and Caucasian participants.
NCT01998958 ↗	A Study to Evaluate the Safety and Efficacy of Intranasal Esketamine in Treatment-resistant Depression	Completed	Janssen Research & Development, LLC	Phase 2	2014-01-27	The purpose of this study is to assess the efficacy and dose response of intranasal esketamine (Panel A: 28 mg, 56 mg, and 84 mg and Panel B: 14 mg and 56 mg) compared with placebo in improving depressive symptoms in participants with treatment-resistant depression (TRD).
NCT02060929 ↗	A Study to Evaluate the Pharmacokinetics of Intranasal Esketamine Administered With and Without a Nasal Guide on the Intranasal Device	Completed	Janssen Research & Development, LLC	Phase 1	2013-10-01	The primary purpose of the study is to evaluate the pharmacokinetics (what the body does to the medication) of intranasally (through the nose) administered esketamine using a device with and without a nasal guide in healthy participants.
NCT02094378 ↗	A Study to Evaluate the Effect of Intranasal Esketamine on Cognitive Functioning in Healthy Subjects	Completed	Janssen Research & Development, LLC	Phase 1	2014-06-01	The purpose of this study is to assess the cognitive effects associated with administration of intranasal esketamine 84 mg.

Clinical Trial Conditions for esketamine hydrochloride

Condition Name

Condition Name for esketamine hydrochloride
Intervention	Trials
Esketamine	18
Healthy	14
Major Depressive Disorder	10
Depression	9

Condition MeSH

Condition MeSH for esketamine hydrochloride
Intervention	Trials
Depression	45
Depressive Disorder	42
Depressive Disorder, Major	19
Depressive Disorder, Treatment-Resistant	18

Clinical Trial Locations for esketamine hydrochloride

Trials by Country

Trials by Country for esketamine hydrochloride
Location	Trials
United States	263
China	54
Belgium	20
Poland	14
Canada	13

Trials by US State

Trials by US State for esketamine hydrochloride
Location	Trials
California	16
Maryland	14
Georgia	14
Ohio	13
New York	13

Clinical Trial Progress for esketamine hydrochloride

Clinical Trial Phase

Clinical Trial Phase for esketamine hydrochloride
Clinical Trial Phase	Trials
Phase 4	33
Phase 3	18
Phase 2/Phase 3	4

Clinical Trial Status

Clinical Trial Status for esketamine hydrochloride
Clinical Trial Phase	Trials
Not yet recruiting	49
Completed	42
Recruiting	37

Clinical Trial Sponsors for esketamine hydrochloride

Sponsor Name

Sponsor Name for esketamine hydrochloride
Sponsor	Trials
Janssen Research & Development, LLC	34
Peking University First Hospital	9
Beijing Tiantan Hospital	5

Sponsor Type

Sponsor Type for esketamine hydrochloride
Sponsor	Trials
Other	125
Industry	46
U.S. Fed	1