Reprometabolic Syndrome Mediates Subfertility in Obesity
Recruiting
University of Colorado, Denver
N/A
2016-06-01
Obesity plays an adverse role at every stage of conception and pregnancy and mounting
evidence implicates relative hypogonadotropic hypogonadism, and reduced menstrual cycle
hormone secretion as likely contributors to the subfertility phenotype and possible
contributors to complications of pregnancy and the developmental origin of adult diseases
such as diabetes and cardiovascular disease. This study will be the first comprehensive
investigation to tie together the patterns of hyperinsulinemia, hyperlipidemia and
inflammation, characteristic of obesity and obesity-caused relative hypogonadotropic
hypogonadotropism and its potential adverse reproductive outcomes. The investigators findings
will be used to inform a subsequent clinical intervention to optimize reproductive outcomes
for obese women and their offspring.
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