Single-Dose Local Radiation Therapy Compared With Ibandronate in Treating Patients With Localized Metastatic Bone Pain
Completed
Cancer Research UK
Phase 3
2003-04-01
RATIONALE: Ibandronate may be effective in reducing bone pain caused by metastatic cancer.
Radiation therapy uses high-energy x-rays to damage tumor cells. It is not yet known whether
ibandronate is more effective than standard treatment with radiation therapy in treating
metastatic bone pain.
PURPOSE: This phase III randomized clinical trial is studying ibandronate to see how well it
works compared to single-dose local radiation therapy in treating patients with localized
metastatic bone pain.
S0307 Phase III Trial of Bisphosphonates as Adjuvant Therapy for Primary Breast Cancer.
Completed
Cancer and Leukemia Group B
Phase 3
2005-07-01
RATIONALE: Zoledronate, clodronate, or ibandronate may delay or prevent bone metastases in
patients with nonmetastatic breast cancer. It is not yet known whether zoledronate is more
effective than clodronate or ibandronate in treating breast cancer.
PURPOSE: This randomized phase III trial is studying zoledronate to see how well it works
compared to clodronate or ibandronate in treating women who have undergone surgery for stage
I, stage II, or stage III breast cancer.
S0307 Phase III Trial of Bisphosphonates as Adjuvant Therapy for Primary Breast Cancer.
Completed
Eastern Cooperative Oncology Group
Phase 3
2005-07-01
RATIONALE: Zoledronate, clodronate, or ibandronate may delay or prevent bone metastases in
patients with nonmetastatic breast cancer. It is not yet known whether zoledronate is more
effective than clodronate or ibandronate in treating breast cancer.
PURPOSE: This randomized phase III trial is studying zoledronate to see how well it works
compared to clodronate or ibandronate in treating women who have undergone surgery for stage
I, stage II, or stage III breast cancer.
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