Safety Study of Ivacaftor in Subjects With Cystic Fibrosis
Completed
Cystic Fibrosis Foundation
Phase 2
2007-05-01
The purpose of this study was to evaluate the safety and tolerability of ivacaftor in
patients with cystic fibrosis (CF) who were aged 18 years or older and have a G551D mutation
in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Ivacaftor is a potent
and selective CFTR potentiator of wild-type, G551D, F508del, and R117H forms of human CFTR
protein. Potentiators are pharmacological agents that increase the chloride ion transport
properties of the channel in the presence of cyclic AMP-dependent protein kinase A (PKA)
activation.
Safety Study of Ivacaftor in Subjects With Cystic Fibrosis
Completed
Cystic Fibrosis Foundation Therapeutics
Phase 2
2007-05-01
The purpose of this study was to evaluate the safety and tolerability of ivacaftor in
patients with cystic fibrosis (CF) who were aged 18 years or older and have a G551D mutation
in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Ivacaftor is a potent
and selective CFTR potentiator of wild-type, G551D, F508del, and R117H forms of human CFTR
protein. Potentiators are pharmacological agents that increase the chloride ion transport
properties of the channel in the presence of cyclic AMP-dependent protein kinase A (PKA)
activation.
Safety Study of Ivacaftor in Subjects With Cystic Fibrosis
Completed
Vertex Pharmaceuticals Incorporated
Phase 2
2007-05-01
The purpose of this study was to evaluate the safety and tolerability of ivacaftor in
patients with cystic fibrosis (CF) who were aged 18 years or older and have a G551D mutation
in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Ivacaftor is a potent
and selective CFTR potentiator of wild-type, G551D, F508del, and R117H forms of human CFTR
protein. Potentiators are pharmacological agents that increase the chloride ion transport
properties of the channel in the presence of cyclic AMP-dependent protein kinase A (PKA)
activation.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors.
Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data.
The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free.
thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user.
Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.
Alerts Available With Subscription
Alerts are available for users with active subscriptions.
