Phase II Study of Lactulose and Circadian Rhythms in Patients With Cirrhosis
Completed
Northwestern University
Phase 2
1994-11-01
OBJECTIVES: I. Assess the effect of lactulose on the circadian rhythm of plasma melatonin in
patients with subclinical hepatic encephalopathy.
II. Assess the intrasubject variability of circadian melatonin levels and neuropsychological
tests.
III. Assess which elements of the neuropsychological test battery show the response to
lactulose.
Phase II Study of Lactulose and Circadian Rhythms in Patients With Cirrhosis
Completed
National Center for Research Resources (NCRR)
Phase 2
1994-11-01
OBJECTIVES: I. Assess the effect of lactulose on the circadian rhythm of plasma melatonin in
patients with subclinical hepatic encephalopathy.
II. Assess the intrasubject variability of circadian melatonin levels and neuropsychological
tests.
III. Assess which elements of the neuropsychological test battery show the response to
lactulose.
Long-term Impact and Intervention for Diarrhea in Brazil
Unknown status
National Institute of Allergy and Infectious Diseases (NIAID)
Phase 3
2006-06-01
The primary objectives of this study are to determine the effect of 1 year supplementation of
Vitamin A, Zinc, and Vitamin A plus Zinc compared to placebo on the Height for Age Z Score
(HAZ) and the number of episodes of diarrhea and number of days of diarrhea at one year in
children living in a Brazilian slum. Study participants will include 280 children ages 2
months to 8 years old, with a Height for Age Z score (HAZ) less than median for the Parque
Universitario community, living in Brazilian favela. There is also a sub study to determine
if ten days of glutamine delivered as an oral bolus improves the health of the digestive
system.
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