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Last Updated: December 25, 2024

CLINICAL TRIALS PROFILE FOR LAROTRECTINIB SULFATE


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All Clinical Trials for larotrectinib sulfate

Trial ID Title Status Sponsor Phase Start Date Summary
NCT02465060 ↗ Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial) Recruiting National Cancer Institute (NCI) Phase 2 2015-08-12 This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Genetic tests look at the unique genetic material (genes) of patients' tumor cells. Patients with genetic abnormalities (such as mutations, amplifications, or translocations) may benefit more from treatment which targets their tumor's particular genetic abnormality. Identifying these genetic abnormalities first may help doctors plan better treatment for patients with solid tumors, lymphomas, or multiple myeloma.
NCT03213704 ↗ Larotrectinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With NTRK Fusions (A Pediatric MATCH Treatment Trial) Recruiting National Cancer Institute (NCI) Phase 2 2017-07-24 This phase II Pediatric MATCH trial studies how well larotrectinib works in treating patients with solid tumors, non-Hodgkin lymphoma, or histiocytic disorders with NTRK fusions that have spread to other places in the body and have come back or do not respond to treatment. Larotrectinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.
NCT03834961 ↗ Larotrectinib in Treating Patients With Previously Untreated TRK Fusion Solid Tumors and TRK Fusion Relapsed Acute Leukemia Recruiting National Cancer Institute (NCI) Phase 2 2019-09-18 This phase II trial studies the side effects and how well larotrectinib works in treating patients with previously untreated TRK fusion solid tumors and TRK fusion acute leukemia that has come back. Larotrectinib may stop the growth of cancer cells with TRK fusions by blocking the TRK enzymes needed for cell growth.
NCT03834961 ↗ Larotrectinib in Treating Patients With Previously Untreated TRK Fusion Solid Tumors and TRK Fusion Relapsed Acute Leukemia Recruiting Children's Oncology Group Phase 2 2019-09-18 This phase II trial studies the side effects and how well larotrectinib works in treating patients with previously untreated TRK fusion solid tumors and TRK fusion acute leukemia that has come back. Larotrectinib may stop the growth of cancer cells with TRK fusions by blocking the TRK enzymes needed for cell growth.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for larotrectinib sulfate

Condition Name

Condition Name for larotrectinib sulfate
Intervention Trials
Recurrent Malignant Solid Neoplasm 2
Recurrent Glioma 2
Advanced Malignant Solid Neoplasm 2
NTRK1 Fusion Positive 2
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Condition MeSH

Condition MeSH for larotrectinib sulfate
Intervention Trials
Neoplasms 4
Lymphoma 2
Nervous System Neoplasms 2
Glioma 2
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Clinical Trial Locations for larotrectinib sulfate

Trials by Country

Trials by Country for larotrectinib sulfate
Location Trials
United States 132
Canada 2
Puerto Rico 2
Guam 1
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Trials by US State

Trials by US State for larotrectinib sulfate
Location Trials
Texas 4
Arkansas 3
Ohio 3
North Carolina 3
Alabama 3
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Clinical Trial Progress for larotrectinib sulfate

Clinical Trial Phase

Clinical Trial Phase for larotrectinib sulfate
Clinical Trial Phase Trials
Phase 2 4
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Clinical Trial Status

Clinical Trial Status for larotrectinib sulfate
Clinical Trial Phase Trials
Recruiting 4
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Clinical Trial Sponsors for larotrectinib sulfate

Sponsor Name

Sponsor Name for larotrectinib sulfate
Sponsor Trials
National Cancer Institute (NCI) 3
Children's Oncology Group 1
M.D. Anderson Cancer Center 1
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Sponsor Type

Sponsor Type for larotrectinib sulfate
Sponsor Trials
NIH 3
Other 2
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