Treatment of Iron Overload With Deferasirox (Exjade) in Hereditary Hemochromatosis and Myelodysplastic Syndrome
Terminated
Novartis
Phase 2
2013-05-01
Hypothesis: Deferasirox can be used as a therapeutic agent to deplete the liver, heart and
bone marrow of excess iron in patients with iron overload caused by myelodysplastic syndrome
(MDS) and hemochromatosis (HC.
Assess the effect of new serum biomarkers (NTBI and hepcidin) and MRI as indicators of iron
overload and their usefulness to monitor iron depletion treatment.
Study the effect of iron overload and iron depletion on intracellular signal transduction,
trace metals concentrations in serum and urine and markers of oxidative stress in blood cells
and urine.
Treatment of Iron Overload With Deferasirox (Exjade) in Hereditary Hemochromatosis and Myelodysplastic Syndrome
Terminated
Haukeland University Hospital
Phase 2
2013-05-01
Hypothesis: Deferasirox can be used as a therapeutic agent to deplete the liver, heart and
bone marrow of excess iron in patients with iron overload caused by myelodysplastic syndrome
(MDS) and hemochromatosis (HC.
Assess the effect of new serum biomarkers (NTBI and hepcidin) and MRI as indicators of iron
overload and their usefulness to monitor iron depletion treatment.
Study the effect of iron overload and iron depletion on intracellular signal transduction,
trace metals concentrations in serum and urine and markers of oxidative stress in blood cells
and urine.
Clinical Studies by Using Alphacait to Screen Drugs for Advanced Solid Tumor
Unknown status
Alphacait, LLC
Phase 2
2017-01-01
This is a single-center, open-label, single-arm, non-randomized study designed to evaluate
PFS, safety, overall survival (OS), objective response rate (OPR), disease control rate (DCR)
and biomarkers of cancer therapy based on Alphacait screening system in subjects with
advanced malignant tumor.
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