CLINICAL TRIALS PROFILE FOR LOXAPINE HYDROCHLORIDE
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All Clinical Trials for loxapine hydrochloride
| Trial ID | Title | Status | Sponsor | Phase | Start Date | Summary |
|---|---|---|---|---|---|---|
| NCT00122733 ↗ | Loxapine and Weaning From Ventilator | Completed | Assistance Publique - Hôpitaux de Paris | N/A | 2005-12-01 | Patients may be very agitated during the weaning period from mechanical ventilation. Administration of loxapine, a neuroleptic that does not notably affect ventilatory drive, may help in obtaining an adequate level of cooperation and, therefore, in reducing the duration of mechanical ventilation. |
| NCT00290082 ↗ | Randomized Double-blind Trial of Midazolam and Loxapine in Agitated Patients | Terminated | University Hospital, Rouen | Phase 3 | 2005-12-01 | Neuroleptics are used since a long time in the management of severely agitated patients. Loxapine is routinely used in our country, with, to our knowledge no severe adverse event reported, in this indication. However, recently, benzodiazepines have appeared interesting in agitated patients, with the use of midazolam. The aim of this study is to compare midazolam to loxapine in the treatment of severe agitated patients admitted in the emergency department. |
| NCT00369577 ↗ | Staccato Loxapine in Agitation (Proof of Concept) | Completed | Alexza Pharmaceuticals, Inc. | Phase 2 | 2006-08-01 | The purpose of this study is to assess efficacy and safety of Staccato Loxapine in the treatment of acute agitation in schizophrenic patients. The study will be conducted in 120 agitated schizophrenic patients - either newly admitted to a hospital setting or a research unit for acute agitation or already in hospital for chronic underlying conditions. Patients meeting entry criteria will be randomized to one of two doses of Staccato Loxapine or to Staccato Placebo. Following administration of study drug, assessment of agitation state will be conducted at serial time points using standard agitation scales over a 24 hour period. |
| NCT00444028 ↗ | Staccato Loxapine Single Dose PK | Completed | Alexza Pharmaceuticals, Inc. | Phase 1 | 2005-09-01 | The objective of this study was to assess the safety, tolerability and pharmacokinetics of a single inhaled dose of (administered in 1 or 2 puffs) Staccato Loxapine in healthy volunteers. |
| NCT00489476 ↗ | Staccato Loxapine in Migraine (in Clinic) | Completed | Alexza Pharmaceuticals, Inc. | Phase 2 | 2007-06-01 | The objective of this trial is to assess the efficacy and safety of Staccato Loxapine in patients with migraine headache with or without aura in a clinical setting. |
| NCT00555412 ↗ | Staccato Loxapine Multidose PK | Completed | Atlanta Center for Medical Research | Phase 1 | 2007-10-01 | The objectives of this trial are to assess the safety, tolerability, and pharmacokinetics of multiple inhaled doses of Staccato Loxapine. |
| NCT00555412 ↗ | Staccato Loxapine Multidose PK | Completed | Alexza Pharmaceuticals, Inc. | Phase 1 | 2007-10-01 | The objectives of this trial are to assess the safety, tolerability, and pharmacokinetics of multiple inhaled doses of Staccato Loxapine. |
| >Trial ID | >Title | >Status | >Sponsor | >Phase | >Start Date | >Summary |
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