Ketamine Infusion Therapy for the Management of Acute Pain in Adult Rib Fracture Patients
Completed
Medical College of Wisconsin
Phase 4
2015-09-01
This study will evaluate the effectiveness of ketamine infusions in the management of acute
pain resulting from broken ribs suffered following a blunt trauma. Half of patients will
receive the institutional standard of care and a placebo infusion (no active medication). The
other half of patients will receive the institutional standard of care and a ketamine
infusion. All subjects and staff will be blinded as to whether they are receiving placebo or
ketamine.
Methocarbamol in Treatment of Muscle Cramps in Cirrhotic Patients
Unknown status
Tanta University
Phase 3
2017-04-01
Muscle cramps markedly affect the quality of life in cirrhotic patients with no highly
effective drug. Methocarbamol is a central muscle relaxant used to treat skeletal muscle
spasms. The mechanism of action of methocarbamol is currently unknown, but may involve the
inhibition of carbonic anhydrase. Methocarbamol has a high therapeutic index, i.e. a wide
range of safe and effective dosages.
Low back pain is a common cause of visit to emergency department. It is not clear if skeletal
muscle relaxants are of benefit for patients with acute low back pain. This is a randomized
study to determine if skeletal muscle relaxants, when combined with naproxen, improve
outcomes more than naproxen alone
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