CLINICAL TRIALS PROFILE FOR OLUMIANT
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All Clinical Trials for olumiant
| Trial ID | Title | Status | Sponsor | Phase | Start Date | Summary |
|---|---|---|---|---|---|---|
| NCT03921554 ↗ | JAK Inhibitor Treatment in AGS | Active, not recruiting | Eli Lilly and Company | Phase 2 | 2019-06-03 | The primary objective of this study is to assess safety as well as efficacy of baricitinib, a Janus Kinase (JAK) inhibitor, in patients with Aicardi Goutières Syndrome (AGS), a multisystem heritable disorder of the innate immunity resulting in excessive interferon production |
| NCT03921554 ↗ | JAK Inhibitor Treatment in AGS | Active, not recruiting | Adeline Vanderver, MD | Phase 2 | 2019-06-03 | The primary objective of this study is to assess safety as well as efficacy of baricitinib, a Janus Kinase (JAK) inhibitor, in patients with Aicardi Goutières Syndrome (AGS), a multisystem heritable disorder of the innate immunity resulting in excessive interferon production |
| NCT04131738 ↗ | Baricitinib for the Prophylaxis of Graft-Versus-Host Disease After Peripheral Blood Hematopoietic Cell Transplantation | Recruiting | Washington University School of Medicine | Phase 1 | 2020-04-07 | In this trial, the investigators will begin to explore the possibility that, as in mice, JAK1/2 inhibition with hematopoietic cell transplantation (HCT) may mitigate graft-versus-host-disease (GVHD) while retaining engraftment and Graft-versus-Leukemia (GVL). Both preclinical and clinical data suggest that inhibition of IFNy and IL-6, directly and using downstream JAK Inhibitors, may be an effective strategy to decrease toxicities and improve disease control for patients undergoing Allogeneic HSCT. Baricitinib, as a JAK1/2 inhibitor, has shown superiority to other JAK inhibitors in preclinical GVHD models. The purpose of this phase I clinical trial is to determine the safety of baricitinib with HSCT measured by the effect on engraftment and grade III-IV acute graft-versus-host-disease (aGVHD). |
| >Trial ID | >Title | >Status | >Sponsor | >Phase | >Start Date | >Summary |
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