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Last Updated: November 22, 2024

CLINICAL TRIALS PROFILE FOR ROFECOXIB


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All Clinical Trials for rofecoxib

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00004845 ↗ A Multicenter Trial of Rofecoxib and Naproxen in Alzheimer's Disease (NSAID Study) Completed Alzheimer's Disease Cooperative Study (ADCS) Phase 2/Phase 3 1969-12-31 The primary specific aim of this clinical trial is to determine whether treatment with rofecoxib or naproxen for one year will slow the rate of decline of cognitive function in patients with Alzheimer's disease (AD) as measured by ADAScog.
NCT00004845 ↗ A Multicenter Trial of Rofecoxib and Naproxen in Alzheimer's Disease (NSAID Study) Completed National Institute on Aging (NIA) Phase 2/Phase 3 1969-12-31 The primary specific aim of this clinical trial is to determine whether treatment with rofecoxib or naproxen for one year will slow the rate of decline of cognitive function in patients with Alzheimer's disease (AD) as measured by ADAScog.
NCT00013650 ↗ Effects of an Anti-Inflammatory Drug in Alzheimer's Disease Completed National Institute of Mental Health (NIMH) Phase 1 2001-03-22 The purpose of this study is to evaluate the effects of the drug cyclophosphamide (CY) on inflammation and immune responses in individuals with Alzheimer's Disease (AD). Inflammation and immunologic response appear to contribute to neurodegeneration in people with AD. In a process called gliosis, the brain immune cells microglia and astroglia undergo activation and possible proliferation, which promotes neuronal injury and death. Activated microglia and astroglia produce compounds that are cytotoxic to neurons, and they express molecules that greatly amplify immune and inflammatory processes in the brain. Excessive glial activation and proliferation are thought to be pivotal events that hasten the demise of synapses and neurons in AD. Fortunately, increased understanding of immune and inflammatory pathology in AD has provided new opportunities for designing disease-altering treatments for AD. Studies suggest that medications such as nonsteroidal anti-inflammatory drugs (NSAIDs) and immunomodulatory agents may have an important role in altering the course of AD. CY is a potent anti-inflammatory and immunomodulatory drug that inhibits proliferation of immune cells. This study will evaluate the effects of CY on individuals with mild to moderate AD. Participants in this study will be randomly assigned to receive either two different doses of CY or placebo (an inactive pill) for 6 months. Participants who receive placebo during the 6 months will have the option of receiving CY for an additional 6 months. Participants will undergo magnetic resonance imaging (MRI) scans of the brain. Measures of cerebral spinal fluid biomarkers or neurodegeneration, neuroinflammation, and neuroimmune activation will be taken. In addition, peripheral lymphocyte subsets and peripheral markers of inflammation will be assessed.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for rofecoxib

Condition Name

Condition Name for rofecoxib
Intervention Trials
Osteoarthritis 5
Postoperative Pain 5
Pain 4
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Condition MeSH

Condition MeSH for rofecoxib
Intervention Trials
Pain, Postoperative 9
Osteoarthritis 8
Toothache 4
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Clinical Trial Locations for rofecoxib

Trials by Country

Trials by Country for rofecoxib
Location Trials
United States 43
Italy 15
Brazil 11
Australia 3
Canada 3
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Trials by US State

Trials by US State for rofecoxib
Location Trials
Maryland 4
Texas 3
Illinois 2
Florida 2
California 2
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Clinical Trial Progress for rofecoxib

Clinical Trial Phase

Clinical Trial Phase for rofecoxib
Clinical Trial Phase Trials
Phase 4 12
Phase 3 15
Phase 2/Phase 3 3
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Clinical Trial Status

Clinical Trial Status for rofecoxib
Clinical Trial Phase Trials
Completed 28
Terminated 8
Unknown status 2
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Clinical Trial Sponsors for rofecoxib

Sponsor Name

Sponsor Name for rofecoxib
Sponsor Trials
Merck Sharp & Dohme Corp. 18
Pfizer 2
National Institute of Dental and Craniofacial Research (NIDCR) 2
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Sponsor Type

Sponsor Type for rofecoxib
Sponsor Trials
Industry 25
Other 16
NIH 5
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