Parathyroid Hormone Levels in Relation to the Phosphorus Content of Meals
Completed
National Center for Research Resources (NCRR)
N/A
1969-12-31
Patients on hemodialysis tend to have chronic elevations in the level of phosphorus in the
blood and a secondary increase in the iPTH level. This chronic elevation in iPTH can have
adverse consequences, thus a variety of phosphate binders are given in an attempt to decrease
the absorption of phosphorus present in the normal diet. Some preliminary studies have
indicated that the iPTH level may change based on the amount of phosphorus present in a meal
prior to any significant absorption of phosphorus. If this is true in hemodialysis patients,
then the timing of the administration of phosphate binders in relation to the ingestion of
meals needs to be considered
Efficacy and Safety of Lanthanum Carbonate and Sevelamer Hydrochloride in Patients Receiving Haemodialysis for End Stage Renal Disease
Completed
Shire
Phase 3
2005-01-07
The purpose of this study is to assess phosphate reduction and control in patients with End
Stage Renal Disease treated with either lanthanum carbonate or sevelamer hydrochloride
Study of Safety and Efficacy of Renagel® Compared With Calcium Acetate in Patients With Peritoneal Dialysis
Completed
Genzyme, a Sanofi Company
Phase 3
2004-12-01
The purpose of this study is to demonstrate that sevelamer hydrochloride is non-inferior to
calcium acetate for the treatment of hyperphosphataemia in patients receiving peritoneal
dialysis.
CARE-2 (Calcium Acetate [PhosLo®]/Sevelamer[Renagel®] Evaluation Study 2) for Heart Calcification in Dialysis Patients
Completed
Nabi Biopharmaceuticals
Phase 4
2005-01-01
The purpose of the study is to evaluate the effects of two phosphate binders, PhosLo and
sevelamer, on heart calcification in dialysis patients. The study will use a non-invasive
technique, electron beam computed tomography (CT) scanning, to measure calcium in the
coronary arteries, the aortic valve, and the mitral valve.
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