Phase I-II Study of Fluorouracil in Combination With Phenylbutyrate in Advanced Colorectal Cancer
Terminated
National Cancer Institute (NCI)
Phase 1/Phase 2
1997-05-01
Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop
growing or die. Interferon-gamma may interfere with the growth of tumor cells and slow the
growth of the tumor. Combining more than one drug with interferon-gamma may kill more tumor
cells. This phase I/II trial is studying the side effects and best dose of giving
fluorouracil together with phenylbutyrate, indomethacin, and interferon-gamma and to see how
well it works in treating patients with stage IV colorectal cancer
Phase II Study of Sodium Phenylbutyrate, Sodium Benzoate, Sodium Phenylacetate, and Dietary Intervention for Urea Cycle Disorders
Completed
Johns Hopkins University
Phase 2
1985-01-01
OBJECTIVES:
I. Assess the safety and efficacy of sodium phenylbutyrate, sodium benzoate, sodium
phenylacetate, and dietary intervention in patients with urea cycle disorders.
Phase II Study of Sodium Phenylbutyrate, Sodium Benzoate, Sodium Phenylacetate, and Dietary Intervention for Urea Cycle Disorders
Completed
National Center for Research Resources (NCRR)
Phase 2
1985-01-01
OBJECTIVES:
I. Assess the safety and efficacy of sodium phenylbutyrate, sodium benzoate, sodium
phenylacetate, and dietary intervention in patients with urea cycle disorders.
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