Efficacy and Safety of Tasimelteon Compared With Placebo in Totally Blind Subjects With Non-24-Hour Sleep-Wake Disorder
Completed
Vanda Pharmaceuticals
Phase 3
2010-08-01
The purpose of this study is to evaluate the efficacy and safety of a six month double-mask
treatment of tasimelteon or placebo in male and female subjects with Non-24-Hour Sleep-Wake
Disorder
Safety Study of Tasimelteon for Treatment of Non-24-Hour-Sleep-Wake Disorder in Blind Individuals With No Light Perception
Unknown status
Vanda Pharmaceuticals
Phase 3
2010-09-01
The purpose of this study is to evaluate the safety of a one year open-label treatment of
tasimelteon in male and female subjects with Non-24-Hour Sleep-Wake Disorder.
Pharmacokinetics of Tasimelteon in Subjects With Mild or Moderate Hepatic Impairment
Completed
Vanda Pharmaceuticals
Phase 1
2011-01-01
The purpose of this research study is to understand whether there is any difference in the
amount of tasimelteon (including its breakdown products) in the blood in individuals with
mild or moderate liver disease compared to individuals who have normal liver function.
A Study to Assess the Effect Tasimelteon on the Cytochrome P450 3A4 and 2C8 Enzymes in Healthy Subjects
Completed
Vanda Pharmaceuticals
Phase 1
2011-08-01
The purpose of this research study is to understand whether there is any difference in the
amount of midazolam (including its breakdown product) in the blood when midazolam is given
with tasimelteon, and whether there is any difference in the amount of rosiglitazone in the
blood when rosiglitazone is given with tasimelteon.
Melatonin Agonist Effects of Tasimelteon Versus Placebo in Patients With Major Depressive Disorder
Completed
Vanda Pharmaceuticals
Phase 2/Phase 3
2011-09-01
The purpose of this study is to evaluate the safety and efficacy of an 8-week double-masked
treatment of tasimelteon or placebo in male and female subjects with Major Depressive
Disorder.
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