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Last Updated: November 22, 2024

CLINICAL TRIALS PROFILE FOR THIORIDAZINE HYDROCHLORIDE


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All Clinical Trials for thioridazine hydrochloride

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00312598 ↗ Body Mass Index (BMI) and Metabolic Changes Following Switch to Aripiprazole From Olanzapine, Risperidone and Quetiapine Completed Bristol-Myers Squibb 2005-08-01 Weight gain is a serious, common side effect of many antipsychotic medications. On average, the highest amounts of weight gain are found to occur in people taking clozaril and olanzapine, but with significant weight gain occuring in those on the other atypical antipsychotics as well. We, the researchers at the University of North Carolina, propose an open-label observational, pilot study of the changes in weight, BMI, body composition, and lipids, glucose, insulin and other metabolic parameters occurring in subjects as they switch from treatment with olanzapine, risperidone or quetiapine to aripiprazole. This medication switch will be determined prior to their entering this study by their treating psychiatrist. We also will determine resting energy expenditure (REE) and respiratory quotient (RQ) as measured by metabolic cart to determine if either energy expenditure or the propensity to store energy as fat may be involved in any changes to weight that are detected. Food intake, hunger, and physical activity will also be assessed.
NCT00312598 ↗ Body Mass Index (BMI) and Metabolic Changes Following Switch to Aripiprazole From Olanzapine, Risperidone and Quetiapine Completed University of North Carolina, Chapel Hill 2005-08-01 Weight gain is a serious, common side effect of many antipsychotic medications. On average, the highest amounts of weight gain are found to occur in people taking clozaril and olanzapine, but with significant weight gain occuring in those on the other atypical antipsychotics as well. We, the researchers at the University of North Carolina, propose an open-label observational, pilot study of the changes in weight, BMI, body composition, and lipids, glucose, insulin and other metabolic parameters occurring in subjects as they switch from treatment with olanzapine, risperidone or quetiapine to aripiprazole. This medication switch will be determined prior to their entering this study by their treating psychiatrist. We also will determine resting energy expenditure (REE) and respiratory quotient (RQ) as measured by metabolic cart to determine if either energy expenditure or the propensity to store energy as fat may be involved in any changes to weight that are detected. Food intake, hunger, and physical activity will also be assessed.
NCT00657514 ↗ Ranolazine Versus Placebo Effects on Exercise Tolerance in Patients With Heart Disease and Peripheral Arterial Disease Withdrawn Colorado Prevention Center Phase 4 2008-05-01 After 6 weeks of maximal Ranolazine therapy, tissue hemoglobin desaturation kinetics will change compared to placebo in patients with chronic angina and peripheral arterial disease.
NCT01765803 ↗ Feasibility of Thioridazine as a Mobilizing Agent for CD34+ Hematopoietic Progenitor Cells Terminated Oxnard Foundation Early Phase 1 2013-06-01 This study will investigate the possibility of using the drug thioridazine (also called Mellaril) to increase the number of certain types of cells moving from the bone marrow to the circulation in a group of healthy humans. The types of cells we hope to collect are called CD34+ progenitor, or stem cells. These cells can be used in the laboratory to better understand a number of diseases and suggest new strategies for therapy. Perhaps the most important potential application of human stem cells is the generation of cells and tissues that could be used for cell-based therapies, as a renewable source of replacement cells and tissues to treat diseases including Alzheimer's diseases, spinal cord injury, stroke, burns, heart disease, diabetes, osteoarthritis, and rheumatoid arthritis.
NCT01765803 ↗ Feasibility of Thioridazine as a Mobilizing Agent for CD34+ Hematopoietic Progenitor Cells Terminated New Mexico Cancer Care Alliance Early Phase 1 2013-06-01 This study will investigate the possibility of using the drug thioridazine (also called Mellaril) to increase the number of certain types of cells moving from the bone marrow to the circulation in a group of healthy humans. The types of cells we hope to collect are called CD34+ progenitor, or stem cells. These cells can be used in the laboratory to better understand a number of diseases and suggest new strategies for therapy. Perhaps the most important potential application of human stem cells is the generation of cells and tissues that could be used for cell-based therapies, as a renewable source of replacement cells and tissues to treat diseases including Alzheimer's diseases, spinal cord injury, stroke, burns, heart disease, diabetes, osteoarthritis, and rheumatoid arthritis.
NCT02096289 ↗ Safety Study of Thioridazine in Combination With Cytarabine to Treat Relapsed or Refractory Acute Myeloid Leukemia Completed Hamilton Health Sciences Corporation Phase 1 2014-07-01 This is a Phase I trial investigating the safety of using thioridazine in addition to cytarabine in elderly patients with relapsed or refractory Acute Myeloid Leukemia.
NCT02096289 ↗ Safety Study of Thioridazine in Combination With Cytarabine to Treat Relapsed or Refractory Acute Myeloid Leukemia Completed Juravinski Cancer Centre Foundation Phase 1 2014-07-01 This is a Phase I trial investigating the safety of using thioridazine in addition to cytarabine in elderly patients with relapsed or refractory Acute Myeloid Leukemia.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for thioridazine hydrochloride

Condition Name

Condition Name for thioridazine hydrochloride
Intervention Trials
Schizophrenia 5
Schizoaffective Disorder 2
Bladder Pain Syndrome 1
Schizoaffective Disorders 1
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Condition MeSH

Condition MeSH for thioridazine hydrochloride
Intervention Trials
Schizophrenia 5
Disease 4
Psychotic Disorders 3
Polyuria 1
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Clinical Trial Locations for thioridazine hydrochloride

Trials by Country

Trials by Country for thioridazine hydrochloride
Location Trials
United States 25
Canada 2
Germany 2
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Trials by US State

Trials by US State for thioridazine hydrochloride
Location Trials
New York 2
Colorado 2
Tennessee 1
Rhode Island 1
Pennsylvania 1
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Clinical Trial Progress for thioridazine hydrochloride

Clinical Trial Phase

Clinical Trial Phase for thioridazine hydrochloride
Clinical Trial Phase Trials
Phase 4 3
Phase 3 1
Phase 1 1
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Clinical Trial Status

Clinical Trial Status for thioridazine hydrochloride
Clinical Trial Phase Trials
Completed 5
Withdrawn 3
Terminated 2
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Clinical Trial Sponsors for thioridazine hydrochloride

Sponsor Name

Sponsor Name for thioridazine hydrochloride
Sponsor Trials
Technische Universität München 1
Hannover Medical School 1
Canadian Institutes of Health Research (CIHR) 1
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Sponsor Type

Sponsor Type for thioridazine hydrochloride
Sponsor Trials
Other 15
Industry 3
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