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Last Updated: November 26, 2024

CLINICAL TRIALS PROFILE FOR TUCATINIB

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All Clinical Trials for tucatinib

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Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
NCT01983501 ↗	A Study of Tucatinib (ONT-380) Combined With Ado-trastuzumab Emtansine (T-DM1) in Patients With HER2+ Breast Cancer	Completed	Cascadian Therapeutics Inc.	Phase 1	2014-02-28	The purpose of this study is to determine the maximal tolerated dose (MTD) or recommended dose (RD) and to assess the safety and tolerability of tucatinib (ONT-380) combined with ado-trastuzumab emtansine (T-DM1) in patients with HER2+ breast cancer.
NCT01983501 ↗	A Study of Tucatinib (ONT-380) Combined With Ado-trastuzumab Emtansine (T-DM1) in Patients With HER2+ Breast Cancer	Completed	Seagen Inc.	Phase 1	2014-02-28	The purpose of this study is to determine the maximal tolerated dose (MTD) or recommended dose (RD) and to assess the safety and tolerability of tucatinib (ONT-380) combined with ado-trastuzumab emtansine (T-DM1) in patients with HER2+ breast cancer.
NCT02025192 ↗	A Study of Tucatinib (ONT-380) Combined With Capecitabine and/or Trastuzumab in Patients With HER2+ Metastatic Breast Cancer	Completed	Cascadian Therapeutics Inc.	Phase 1	2013-12-31	The purpose of this study is to determine the maximal tolerated dose (MTD) or recommended phase 2 dose (RP2D) of tucatinib (ONT-380) and to assess the safety and tolerability of tucatinib (ONT-380) combined with capecitabine alone, trastuzumab alone and with both capecitabine and trastuzumab in patients with HER2+ metastatic breast cancer.
>Trial ID	>Title	>Status	>Sponsor	>Phase	>Start Date	>Summary

Clinical Trial Conditions for tucatinib

Condition Name

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Condition Name for tucatinib
Intervention	Trials
Breast Cancer	10
HER2-positive Breast Cancer	7
Metastatic Breast Cancer	4
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Condition MeSH

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Condition MeSH for tucatinib
Intervention	Trials
Breast Neoplasms	32
Colorectal Neoplasms	7
Adenocarcinoma	7
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Clinical Trial Locations for tucatinib

Trials by Country

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Trials by Country for tucatinib
Location	Trials
United States	319
Canada	23
Spain	17
Japan	11
Korea, Republic of	7
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Trials by US State

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Trials by US State for tucatinib
Location	Trials
California	19
Texas	19
Washington	14
Tennessee	14
New York	13
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Clinical Trial Progress for tucatinib

Clinical Trial Phase

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Clinical Trial Phase for tucatinib
Clinical Trial Phase	Trials
Phase 4	1
Phase 3	5
Phase 2/Phase 3	1
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Clinical Trial Status

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Clinical Trial Status for tucatinib
Clinical Trial Phase	Trials
Recruiting	20
Not yet recruiting	19
Completed	8
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Clinical Trial Sponsors for tucatinib

Sponsor Name

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Sponsor Name for tucatinib
Sponsor	Trials
Seagen Inc.	34
Seattle Genetics, Inc.	13
Cascadian Therapeutics Inc.	5
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Sponsor Type

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Sponsor Type for tucatinib
Sponsor	Trials
Industry	73
Other	38
NIH	4
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