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Last Updated: December 23, 2024

CLINICAL TRIALS PROFILE FOR VORINOSTAT


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All Clinical Trials for vorinostat

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00005634 ↗ Suberoylanilide Hydroxamic Acid in Treating Patients With Advanced Solid Tumors That Have Not Responded to Previous Therapy Completed National Cancer Institute (NCI) Phase 1 2000-01-01 RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of suberoylanilide hydroxamic acid in treating patients who have advanced primary or metastatic solid tumors that have not responded to previous therapy.
NCT00005634 ↗ Suberoylanilide Hydroxamic Acid in Treating Patients With Advanced Solid Tumors That Have Not Responded to Previous Therapy Completed Memorial Sloan Kettering Cancer Center Phase 1 2000-01-01 RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of suberoylanilide hydroxamic acid in treating patients who have advanced primary or metastatic solid tumors that have not responded to previous therapy.
NCT00007345 ↗ Depsipeptide to Treat Patients With Cutaneous T-Cell Lymphoma and Peripheral T-Cell Lymphoma Completed National Cancer Institute (NCI) Phase 2 2001-03-08 Background: NSC630176 is a depsipeptide fermentation product from Chromobacterium violaceum with potent cytotoxic activity against human tumor cell lines and in vivo efficacy against both human tumor xenografts and murine tumors (1-3). NSC 630176, herein referred to as depsipeptide, shows a lack of cross resistance with several commonly used cytotoxic agents such as vincristine, 5-fluorouracil, mitomycin C and cyclophosphamide (2). However, it has been defined as a P-glycoprotein (Pgp) substrate by COMPARE analysis of the National Cancer Institute (NCI) drug screen cytotoxicity profile (4). Depsipeptide is a member of a novel class of antineoplastic agents, the histone deacetylase inhibitors. In the phase I trial conducted at the National Cancer Institute (NCI), responses were observed at the maximum tolerated dose (MTD) in patients with cutaneous and peripheral T-cell lymphoma. Objectives: In patients with cutaneous T-cell lymphoma, the primary end points to be examined are overall response rate, complete response rate and duration of response. In patients with relapsed peripheral T-cell lymphoma, the endpoints to be examined are overall response rate and complete response rate. To evaluate the tolerability of depsipeptide with extended cycles of therapy. Eligibility: Patients with cutaneous T-cell lymphoma (mycosis fungoides or Sezary syndrome) or other peripheral T-cell lymphomas are eligible. Design: Depsipeptide will be administered at 14 mg/m^2, over 4 hours on days 1, 8 and 15. This trial will accrue in six cohorts; Arm 1, patients with cutaneous T-cell lymphoma who have had less than or equal to two prior cytotoxic chemotherapy regimens; Arm 2, patients with peripheral T-cell lymphoma who have had less than or equal to two prior cytotoxic chemotherapy regimens; Arm 3, patients with cutaneous and peripheral T-cell lymphoma who have had more than two prior cytotoxic chemotherapy regimens; Arm 4, patients with other mature T-cell lymphomas; Arm 5, a replicate arm of arm 1; Arm 6, patients with peripheral T-cell lymphoma who have had more than two prior cytotoxic chemotherapy regimens; Arm 7, patients with cutaneous T cell lymphoma who have received vorinostat. Dose may be adjusted based on toxicities.
NCT00045006 ↗ Suberoylanilide Hydroxamic Acid in Treating Patients With Advanced Cancer Completed National Cancer Institute (NCI) Phase 1 2001-07-01 RATIONALE: Suberoylanilide hydroxamic acid may stop the growth of cancer cells by blocking the enzymes necessary for cancer cell growth. PURPOSE: Phase I trial to study the effectiveness of suberoylanilide hydroxamic acid in treating patients who have advanced cancer.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for vorinostat

Condition Name

Condition Name for vorinostat
Intervention Trials
Lymphoma 23
Multiple Myeloma 14
Unspecified Adult Solid Tumor, Protocol Specific 12
Breast Cancer 10
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Condition MeSH

Condition MeSH for vorinostat
Intervention Trials
Lymphoma 60
Leukemia 44
Leukemia, Myeloid, Acute 32
Leukemia, Myeloid 30
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Clinical Trial Locations for vorinostat

Trials by Country

Trials by Country for vorinostat
Location Trials
United States 761
Canada 45
Japan 21
Australia 18
United Kingdom 17
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Trials by US State

Trials by US State for vorinostat
Location Trials
Texas 55
California 55
Pennsylvania 43
New York 42
Maryland 34
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Clinical Trial Progress for vorinostat

Clinical Trial Phase

Clinical Trial Phase for vorinostat
Clinical Trial Phase Trials
Phase 4 1
Phase 3 8
Phase 2/Phase 3 3
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Clinical Trial Status

Clinical Trial Status for vorinostat
Clinical Trial Phase Trials
Completed 142
Terminated 54
Active, not recruiting 30
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Clinical Trial Sponsors for vorinostat

Sponsor Name

Sponsor Name for vorinostat
Sponsor Trials
National Cancer Institute (NCI) 96
Merck Sharp & Dohme Corp. 90
M.D. Anderson Cancer Center 22
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Sponsor Type

Sponsor Type for vorinostat
Sponsor Trials
Other 311
Industry 146
NIH 107
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