Zileuton in Preventing Lung Cancer in Patients With Bronchial Dysplasia
Completed
National Cancer Institute (NCI)
Phase 2
2003-06-01
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the
development or recurrence of cancer. The use of zileuton may be an effective way to prevent
lung cancer in patients who have bronchial dysplasia.
PURPOSE: Randomized phase II trial to study the effectiveness of zileuton in preventing lung
cancer in patients who have bronchial dysplasia.
Zileuton in Preventing Lung Cancer in Patients With Bronchial Dysplasia
Completed
Barbara Ann Karmanos Cancer Institute
Phase 2
2003-06-01
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the
development or recurrence of cancer. The use of zileuton may be an effective way to prevent
lung cancer in patients who have bronchial dysplasia.
PURPOSE: Randomized phase II trial to study the effectiveness of zileuton in preventing lung
cancer in patients who have bronchial dysplasia.
Carboplatin and Gemcitabine Combined With Celecoxib and/or Zileuton in Treating Patients With Advanced Non-Small Cell Lung Cancer
Completed
National Cancer Institute (NCI)
Phase 2
2003-12-01
RATIONALE: Drugs used in chemotherapy, such as carboplatin and gemcitabine, work in different
ways to stop tumor cells from dividing so they stop growing or die. Celecoxib and zileuton
may stop the growth of tumor cells by stopping blood flow to the tumor and may block the
enzymes necessary for tumor cell growth. Combining chemotherapy with celecoxib and/or
zileuton may kill more tumor cells.
PURPOSE: Randomized phase II trial to study the effectiveness of combining celecoxib and/or
zileuton with carboplatin and gemcitabine in treating patients who have advanced non-small
cell lung cancer.
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